PMID- 6178588
OWN - NLM
STAT- MEDLINE
DCOM- 19820910
LR  - 20190813
IS  - 0340-6199 (Print)
IS  - 0340-6199 (Linking)
VI  - 138
IP  - 2
DP  - 1982 Mar
TI  - Subacute sclerosing panencephalitis in a brother and sister. Therapeutic trial of 
      fibroblast interferon.
PG  - 187-90
AB  - This paper describes the very rare occurrence of subacute sclerosing 
      panencephalitis (SSPE) in two siblings: a Turkish boy and his younger sister. The 
      clinical picture was characteristic, and the diagnosis was confirmed in both 
      cases by appropriate laboratory examination. The interval between the occurrence 
      of the first neurological symptoms in the boy, and subsequently in the girl was 
      four years. Study of HLA- and 27 other polymorphic marker-systems did not reveal 
      linkage to one of the systems tested. Therapeutic trials in the girl included 
      intravenous and intraventricular application of a total of 87 X 10(6) U human 
      fibroblast interferon (Hu INF-beta) over 21 days. However, up to 3 months after 
      the end of interferon administration there were no significant changes in the 
      girl's condition.
FAU - Bartram, C R
AU  - Bartram CR
FAU - Henke, J
AU  - Henke J
FAU - Treuner, J
AU  - Treuner J
FAU - Basler, M
AU  - Basler M
FAU - Esch, A
AU  - Esch A
FAU - Mortier, W
AU  - Mortier W
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Germany
TA  - Eur J Pediatr
JT  - European journal of pediatrics
JID - 7603873
RN  - 0 (HLA Antigens)
RN  - 9008-11-1 (Interferons)
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Female
MH  - Fibroblasts
MH  - HLA Antigens/analysis
MH  - Humans
MH  - Interferons/*therapeutic use
MH  - Male
MH  - Subacute Sclerosing Panencephalitis/*genetics/therapy
EDAT- 1982/03/01 00:00
MHDA- 1982/03/01 00:01
CRDT- 1982/03/01 00:00
PHST- 1982/03/01 00:00 [pubmed]
PHST- 1982/03/01 00:01 [medline]
PHST- 1982/03/01 00:00 [entrez]
AID - 10.1007/BF00441152 [doi]
PST - ppublish
SO  - Eur J Pediatr. 1982 Mar;138(2):187-90. doi: 10.1007/BF00441152.