PMID- 6182418
OWN - NLM
STAT- MEDLINE
DCOM- 19821216
LR  - 20190724
IS  - 0160-2446 (Print)
IS  - 0160-2446 (Linking)
VI  - 4
IP  - 5
DP  - 1982 Sep-Oct
TI  - Oral nifedipine in the long-term management of severe chronic heart failure.
PG  - 847-55
AB  - We evaluated the hemodynamic effects of nifedipine in 10 symptomatic patients 
      with chronic refractory heart failure due to idiopathic cardiomyopathy. 
      Nifedipine significantly increased cardiac index (from 1.80 +/- 0.4 to 3 +/- 0.6 
      L/min/m2), stroke volume index (from 21 +/- 6 to 33 +/- 8 ml/beat/m2), and stroke 
      work index (from 17.9 +/- 7 to 25.5 +/- 7 g-m/m2). The drugs also produced a 
      significant decrease in left ventricular filling pressure (from 24.6 +/- 3 to 19 
      +/- 2 mm Hg), mean blood pressure (from 86 +/- 9 to 74 +/- 5 mm Hg), mean 
      pulmonary arterial pressure (from 31.9 +/- 5 to 25.6 +/- 3 mm Hg), total systemic 
      vascular resistance (from 2,104 +/- 329 to 1,088 +/- 249 dyn/s/cm-5), and 
      pulmonary vascular resistance (from 200 +/- 71 to 107 +/- 50 dyn/s/cm-5). Heart 
      rate remained unchanged. In all patients maintained on nifedipine therapy, repeat 
      hemodynamic studies at 2 months revealed sustained effects, and all patients had 
      symptomatic improvement of at least one New York Heart Association (NYHA) 
      functional class. Long-term treatment was well tolerated. Forty-eight hours after 
      discontinuation of nifedipine administration the hemodynamic benefits were lost. 
      We conclude that nifedipine may be of value for long-term ambulatory therapy of 
      severe chronic heart failure.
FAU - Bellocci, F
AU  - Bellocci F
FAU - Ansalone, G
AU  - Ansalone G
FAU - Santarelli, P
AU  - Santarelli P
FAU - Loperfido, F
AU  - Loperfido F
FAU - Scabbia, E
AU  - Scabbia E
FAU - Zecchi, P
AU  - Zecchi P
FAU - Manzoli, U
AU  - Manzoli U
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Cardiovasc Pharmacol
JT  - Journal of cardiovascular pharmacology
JID - 7902492
RN  - 0 (Pyridines)
RN  - I9ZF7L6G2L (Nifedipine)
SB  - IM
MH  - Administration, Oral
MH  - Adult
MH  - Blood Pressure/drug effects
MH  - Female
MH  - Heart Failure/*drug therapy/physiopathology
MH  - Heart Rate/drug effects
MH  - Hemodynamics/*drug effects
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nifedipine/*administration & dosage/pharmacology
MH  - Pyridines/*administration & dosage
MH  - Stroke Volume/drug effects
MH  - Time Factors
EDAT- 1982/09/01 00:00
MHDA- 1982/09/01 00:01
CRDT- 1982/09/01 00:00
PHST- 1982/09/01 00:00 [pubmed]
PHST- 1982/09/01 00:01 [medline]
PHST- 1982/09/01 00:00 [entrez]
AID - 10.1097/00005344-198209000-00022 [doi]
PST - ppublish
SO  - J Cardiovasc Pharmacol. 1982 Sep-Oct;4(5):847-55. doi: 
      10.1097/00005344-198209000-00022.