PMID- 6187790
OWN - NLM
STAT- MEDLINE
DCOM- 19830505
LR  - 20190723
IS  - 0091-6749 (Print)
IS  - 0091-6749 (Linking)
VI  - 71
IP  - 4
DP  - 1983 Apr
TI  - Induction of late cutaneous reaction by kallikrein injection: comparison with 
      allergic-like late response to compound 48/80.
PG  - 363-70
AB  - Although IgE antibody is able to provoke a late cutaneous allergic response 
      (LCAR), the mechanism of its development is not clear. It seems to involve 
      vasoactive and clotting mediators released from mast cells and basophils. 
      Substances biologically similar to plasma kallikrein (KK), a Hageman factor 
      activator, have been shown to be released by basophils in the course of an 
      IgE-dependent reaction. Because compound 48/80 induces LCAR-like responses in the 
      skin, we compared the ability of tissue KK and compound 48/80 to induce late 
      cutaneous reactions (LCRs). All 40 test subjects showed an immediate wheal and 
      flare reaction (WF) after both KK and 48/80. The WF was followed by an LCR 
      characterized by diffuse edema, pain, and erythema in 36 of 40 subjects with 
      48/80 and 26 of 40 with KK. The LCRs evoked by the two agents did not differ in 
      their appearance or in their time of development. These reactions increased until 
      the 5 hr mark, began to decrease at the 10 hr mark, and were gone after 24 hr. 
      Histologic study showed edema and a mixed cell infiltration with fibrin 
      deposition. Challenge of the original injection site and a new site after 1 or 2 
      wk showed a local refractory state lasting 2 wk. Prednisone almost totally 
      suppressed the LCRs induced by both KK and 48/80.
FAU - Dor, P J
AU  - Dor PJ
FAU - Vervloet, D
AU  - Vervloet D
FAU - Sapene, M
AU  - Sapene M
FAU - Andrac, L
AU  - Andrac L
FAU - Bonerandi, J J
AU  - Bonerandi JJ
FAU - Charpin, J
AU  - Charpin J
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - J Allergy Clin Immunol
JT  - The Journal of allergy and clinical immunology
JID - 1275002
RN  - 4091-50-3 (p-Methoxy-N-methylphenethylamine)
RN  - 9001-31-4 (Fibrin)
RN  - EC 3.4.21.- (Kallikreins)
RN  - VB0R961HZT (Prednisone)
SB  - IM
MH  - Biopsy
MH  - Fibrin/analysis
MH  - Fluorescent Antibody Technique
MH  - Histamine Release
MH  - Humans
MH  - Injections, Subcutaneous
MH  - Kallikreins/*administration & dosage
MH  - Passive Cutaneous Anaphylaxis/*drug effects
MH  - Prednisone/administration & dosage
MH  - Skin/anatomy & histology/pathology
MH  - Skin Tests
MH  - Time Factors
MH  - p-Methoxy-N-methylphenethylamine/*administration & dosage
EDAT- 1983/04/01 00:00
MHDA- 1983/04/01 00:01
CRDT- 1983/04/01 00:00
PHST- 1983/04/01 00:00 [pubmed]
PHST- 1983/04/01 00:01 [medline]
PHST- 1983/04/01 00:00 [entrez]
AID - 0091-6749(83)90063-5 [pii]
AID - 10.1016/0091-6749(83)90063-5 [doi]
PST - ppublish
SO  - J Allergy Clin Immunol. 1983 Apr;71(4):363-70. doi: 10.1016/0091-6749(83)90063-5.