PMID- 6189432
OWN - NLM
STAT- MEDLINE
DCOM- 19830617
LR  - 20061115
IS  - 0003-4738 (Print)
IS  - 0003-4738 (Linking)
VI  - 50
IP  - 5
DP  - 1983 May
TI  - Interferon increases IgE binding to basophils.
PG  - 305-8
AB  - One of the pivotal manifestations of immediate type hypersensitivity is mediator 
      release from a variety of mediator cells, e.g., mast cells and basophils. The 
      essential step of this process is the binding of immunoglobulin E (IgE) to the 
      surface of these cells. In the present studies we examined the influence of human 
      interferon (HuIFN) on the binding of IgE to human leukocytes (basophils). The 
      results of these studies indicate that pre-treatment of leukocytes (basophils) 
      with different types of IFN leads to a pronounced increase in binding of IgE to 
      these cells. These data support the hypothesis concerning a pathogenetic role of 
      IFN in the development of allergy of the immediate type hypersensitivity.
FAU - Skurkovich, S
AU  - Skurkovich S
FAU - Skurkovich, B
AU  - Skurkovich B
FAU - Bellanti, J A
AU  - Bellanti JA
FAU - Banerjee, D K
AU  - Banerjee DK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Ann Allergy
JT  - Annals of allergy
JID - 0372346
RN  - 0 (Interferon Type I)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9008-11-1 (Interferons)
SB  - IM
MH  - Basophils/*metabolism
MH  - Humans
MH  - Hypersensitivity, Immediate
MH  - Immunoglobulin E/*metabolism
MH  - Interferon Type I/pharmacology
MH  - Interferons/*pharmacology
MH  - Protein Binding
MH  - Stimulation, Chemical
EDAT- 1983/05/01 00:00
MHDA- 1983/05/01 00:01
CRDT- 1983/05/01 00:00
PHST- 1983/05/01 00:00 [pubmed]
PHST- 1983/05/01 00:01 [medline]
PHST- 1983/05/01 00:00 [entrez]
PST - ppublish
SO  - Ann Allergy. 1983 May;50(5):305-8.