PMID- 619604
OWN - NLM
STAT- MEDLINE
DCOM- 19780223
LR  - 20180330
IS  - 0002-9165 (Print)
IS  - 0002-9165 (Linking)
VI  - 31
IP  - 1
DP  - 1978 Jan
TI  - Influence of diet on leg uptake of glucose during heavy exercise.
PG  - 62-7
AB  - Four young men each performed three treadmill walks to exhaustion at 70% of their 
      respective O2 uptake maxima. Each walk followed 3 days consumption of either a 
      normal mixed (M), high fat and protein (F-P), or high carbohydrate (CHO) diet. 
      The fractional use of carbohydrates for energy during the initial 1/2-hr of work 
      was significantly reduced following the F-P diet as compared with the M or CHO 
      diets (P less than 0.005), averaging 38.2% (F-P), 69.9% (M), and 71.9 (CHO). 
      Carbohydrates energy production was negatively correlated with blood levels of 
      both free fatty acids ( r = -0.62, P less than 0.05) and beta-OH-butyrate (r = - 
      0.79, P less than 0.005). Work time to exhaustion was closely correlated with the 
      fractional usage of carbohydrates for energy (r = 0.86, P less than 0.001). The 
      femoral arteriovenous blood glucose difference was directly related to the 
      pre-work dietary carbohydrate fraction, with the 30-min work means 0.25 mM (F-P), 
      0.34 mM (M), and 0.52 mM (CHO). Estimation of leg arteriovenous O2 difference 
      indicated that leg uptake of blood-borne glucose provided approximately 23 +/- 
      10% (F-P), 30 +/- 8% (M), and 46 +/- 13% (CHO) of the legs' aerobic substrate 
      during the first 30 min of work. These results provide further evidence for the 
      shift from noncarbohydrate to carbohydrate energy sources during exercise as the 
      carbohydrate fraction of the diet is elevated.
FAU - Martin, B
AU  - Martin B
FAU - Robinson, S
AU  - Robinson S
FAU - Robertshaw, D
AU  - Robertshaw D
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Clin Nutr
JT  - The American journal of clinical nutrition
JID - 0376027
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Fats)
RN  - 0 (Fatty Acids, Nonesterified)
RN  - 0 (Hydroxybutyrates)
RN  - IY9XDZ35W2 (Glucose)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Adult
MH  - Dietary Carbohydrates/administration & dosage
MH  - Dietary Fats/administration & dosage
MH  - Energy Metabolism
MH  - Fatty Acids, Nonesterified/blood
MH  - Glucose/*metabolism
MH  - Humans
MH  - Hydroxybutyrates/blood
MH  - Leg/blood supply/*metabolism
MH  - Male
MH  - Oxygen
MH  - *Physical Exertion
EDAT- 1978/01/01 00:00
MHDA- 1978/01/01 00:01
CRDT- 1978/01/01 00:00
PHST- 1978/01/01 00:00 [pubmed]
PHST- 1978/01/01 00:01 [medline]
PHST- 1978/01/01 00:00 [entrez]
AID - 10.1093/ajcn/31.1.62 [doi]
PST - ppublish
SO  - Am J Clin Nutr. 1978 Jan;31(1):62-7. doi: 10.1093/ajcn/31.1.62.