PMID- 6196353
OWN - NLM
STAT- MEDLINE
DCOM- 19840127
LR  - 20190511
IS  - 0021-924X (Print)
IS  - 0021-924X (Linking)
VI  - 94
IP  - 3
DP  - 1983 Sep
TI  - Tryptophan metabolism in analbuminemic rats.
PG  - 623-32
AB  - Studies were made on tryptophan metabolism in Nagase analbuminemic rats (NAR), a 
      mutant strain established from Sprague-Dawley rats that is characterized by lack 
      of plasma albumin and hyperlipidemia. The total tryptophan concentration in NAR 
      plasma is one fifth of normal, but the plasma free tryptophan concentration and 
      liver and brain tryptophan levels are normal. Radioimmunoelectrophoresis showed 
      that the tryptophan binding protein in NAR plasma is alpha 2-macroglobulin. The 
      effect of oral tryptophan loading on plasma tryptophan and urinary excretion of 
      tryptophan and its metabolites were examined. Differences between the values for 
      NAR and normal rats were not significant except that the disappearance rate of 
      tryptophan from NAR plasma was faster than in normal rats. The effects of several 
      drugs that influence the concentration of non-esterified fatty acid (NEFA) or 
      amino acids in the plasma of normal rats on NAR plasma tryptophan and NEFA 
      concentrations and brain tryptophan metabolism were investigated. These drugs did 
      not alter plasma NEFA and free tryptophan in NAR in the same direction as in 
      normal rats. This difference may be caused by the difference of tryptophan 
      binding proteins in the plasma of these two strains.
FAU - Emori, T
AU  - Emori T
FAU - Sugiyama, K
AU  - Sugiyama K
FAU - Nagase, S
AU  - Nagase S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Biochem
JT  - Journal of biochemistry
JID - 0376600
RN  - 0 (Amino Acids)
RN  - 0 (Serum Albumin)
RN  - 333DO1RDJY (Serotonin)
RN  - 54-16-0 (Hydroxyindoleacetic Acid)
RN  - 8DUH1N11BX (Tryptophan)
SB  - IM
MH  - Amino Acids/blood
MH  - Animals
MH  - Brain/metabolism
MH  - Hydroxyindoleacetic Acid/metabolism
MH  - Hyperlipidemias/complications/metabolism
MH  - Liver/metabolism
MH  - Rats
MH  - Rats, Mutant Strains
MH  - Reference Values
MH  - Serotonin/metabolism
MH  - Serum Albumin/*deficiency
MH  - Tryptophan/blood/*metabolism
EDAT- 1983/09/01 00:00
MHDA- 1983/09/01 00:01
CRDT- 1983/09/01 00:00
PHST- 1983/09/01 00:00 [pubmed]
PHST- 1983/09/01 00:01 [medline]
PHST- 1983/09/01 00:00 [entrez]
AID - 10.1093/oxfordjournals.jbchem.a134402 [doi]
PST - ppublish
SO  - J Biochem. 1983 Sep;94(3):623-32. doi: 10.1093/oxfordjournals.jbchem.a134402.