PMID- 6196637
OWN - NLM
STAT- MEDLINE
DCOM- 19840107
LR  - 20131121
IS  - 0148-639X (Print)
IS  - 0148-639X (Linking)
VI  - 6
IP  - 8
DP  - 1983 Oct
TI  - Maturational defect of regenerating muscle fibers in cases with Duchenne and 
      congenital muscular dystrophies.
PG  - 545-52
AB  - Immature fibers in Duchenne muscular dystrophy (DMD) and congenital muscular 
      dystrophies (CMD) were compared with human fetal muscles and 
      experimentally-induced regenerating muscle fibers using the acridine orange (AO) 
      technique on fluorescent microscopy and histochemical methods. Strong AO activity 
      was observed on immature fibers in dystrophies and on experimentally-induced 
      fibers in the early stages of regeneration. These young fibers showed type 2C 
      histochemical reactions on ATPase stains. Human fetal muscles failed to show 
      these fibers which were seen in the muscular dystrophies and the experimental 
      regenerating muscle. From these results it is concluded that immature fibers in 
      muscular dystrophies are early stages of regenerating fibers and not 
      maturationally arrested fetal muscle fibers. In addition, these immature fibers 
      formed small groups composed of 10 to 50 fibers in muscular dystrophies and 
      sometimes large groups in CMD. It is suggested that the investigation of immature 
      fibers and their grouping is quite important for revealing the pathogenesis of 
      the muscular dystrophies.
FAU - Miike, T
AU  - Miike T
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Muscle Nerve
JT  - Muscle & nerve
JID - 7803146
RN  - 63231-63-0 (RNA)
RN  - F30N4O6XVV (Acridine Orange)
SB  - IM
MH  - Acridine Orange
MH  - Child, Preschool
MH  - Female
MH  - Histocytochemistry
MH  - Humans
MH  - Infant
MH  - Male
MH  - Muscles/embryology/metabolism/*pathology
MH  - Muscular Dystrophies/congenital/metabolism/*pathology
MH  - RNA/metabolism
MH  - Syndrome
EDAT- 1983/10/01 00:00
MHDA- 1983/10/01 00:01
CRDT- 1983/10/01 00:00
PHST- 1983/10/01 00:00 [pubmed]
PHST- 1983/10/01 00:01 [medline]
PHST- 1983/10/01 00:00 [entrez]
AID - 10.1002/mus.880060802 [doi]
PST - ppublish
SO  - Muscle Nerve. 1983 Oct;6(8):545-52. doi: 10.1002/mus.880060802.