PMID- 6197027
OWN - NLM
STAT- MEDLINE
DCOM- 19840107
LR  - 20190919
IS  - 0166-3542 (Print)
IS  - 0166-3542 (Linking)
VI  - 3
IP  - 3
DP  - 1983 Sep
TI  - Comparison of the antiviral effects of 
      5-methoxymethyldeoxyuridine-5'-monophosphate with adenine 
      arabinoside-5'-monophosphate.
PG  - 161-74
AB  - Methoxymethyldeoxyuridine-5'-monophosphate (MMUdR-MP) and 
      arabinofuranosyladenine-5'-monophosphate (Ara-AMP) had significant antiviral 
      activity against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in RK-13 
      and Vero cells. MMUdR-MP and Ara-AMP were more potent than 
      methoxymethyldeoxyuridine (MMUdR) and arabinofuranosyladenine (Ara-A) against the 
      MS strain of HSV-2. MMUdR-MP inhibited replication of HSV-1r (mutant resistant to 
      MMUdR). MMUdR in combination with Ara-AMP showed additive activity; whereas the 
      MMUdR-MP and Ara-AMP combination was antagonistic against herpes viruses. MMUdR 
      in combination with Ara-A was synergistic in reducing the log virus yield. 
      Cytotoxicity (microscopic lesions) was observed on exposure to MMUdR-MP and 
      Ara-AMP at 450 and 90 microM, respectively. Rapidly proliferating RK-13 cells 
      exposed to Ara-AMP (64 microM) were killed. In the same system, the cells 
      surviving after incubation with MMUdR-MP (650 microM), multiplied at an almost 
      normal rate.
FAU - Ayisi, N K
AU  - Ayisi NK
FAU - Meldrum, J B
AU  - Meldrum JB
FAU - Stuart, A L
AU  - Stuart AL
FAU - Gupta, V S
AU  - Gupta VS
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Antiviral Res
JT  - Antiviral research
JID - 8109699
RN  - 0 (Antiviral Agents)
RN  - 0 (Arabinonucleotides)
RN  - 0 (Thymine Nucleotides)
RN  - 106XV160TZ (Vidarabine Phosphate)
RN  - 365-07-1 (Thymidine Monophosphate)
RN  - 5116-22-3 (5-methoxymethyl-2'-deoxyuridine)
RN  - 53212-98-9 (5-methoxymethyl-2'-deoxyuridine-5'-monophosphate)
RN  - FA2DM6879K (Vidarabine)
RN  - W78I7AY22C (Deoxyuridine)
SB  - IM
MH  - Animals
MH  - Antiviral Agents/*pharmacology/toxicity
MH  - Arabinonucleotides/*pharmacology
MH  - Cell Survival/drug effects
MH  - Deoxyuridine/analogs & derivatives/*pharmacology
MH  - Rabbits
MH  - Simplexvirus/drug effects
MH  - *Thymidine Monophosphate/*analogs & derivatives
MH  - Thymine Nucleotides/*pharmacology
MH  - Vidarabine/pharmacology
MH  - Vidarabine Phosphate/*pharmacology
MH  - Viral Plaque Assay
MH  - Virus Replication/drug effects
EDAT- 1983/09/01 00:00
MHDA- 1983/09/01 00:01
CRDT- 1983/09/01 00:00
PHST- 1983/09/01 00:00 [pubmed]
PHST- 1983/09/01 00:01 [medline]
PHST- 1983/09/01 00:00 [entrez]
AID - 0166-3542(83)90023-2 [pii]
AID - 10.1016/0166-3542(83)90023-2 [doi]
PST - ppublish
SO  - Antiviral Res. 1983 Sep;3(3):161-74. doi: 10.1016/0166-3542(83)90023-2.