PMID- 6197315
OWN - NLM
STAT- MEDLINE
DCOM- 19840214
LR  - 20191023
IS  - 0007-5124 (Print)
IS  - 0007-5124 (Linking)
VI  - 32
IP  - 3
DP  - 1983 Jul
TI  - Age-related changes in plasma proteins of analbuminemic rats.
PG  - 123-32
AB  - A mutant strain, Nagase analbuminemia rats (NAR), was established from 
      Sprague-Dawley rats. Age-related changes in plasma proteins of NAR were 
      investigated to obtain information of their abnormalities of protein metabolism. 
      The total protein concentration in the serum of NAR of various ages was almost 
      the same as that of normal rats of the same age. The albumin level of NAR was 
      less than 0.05 mg/ml at all ages examined. The concentrations of serum alpha 
      1-antitrypsin, alpha-X protein, alpha 2-macroglobulin, transferrin, 
      ceruloplasmin, IgG, IgA and IgM were higher in NAR than in normal rats except for 
      the perinatal stage, but alpha 1-acid glycoprotein level in NAR was normal. The 
      serum transferrin and ceruloplasmin levels were especially high in female adult 
      NAR. The plasma fibrinogen concentration was also increased in NAR. These 
      findings indicate that the normal total serum protein level of NAR was maintained 
      by increase in the globulin concentration.
FAU - Emori, T
AU  - Emori T
FAU - Takahashi, M
AU  - Takahashi M
FAU - Sugiyama, K
AU  - Sugiyama K
FAU - Shumiya, S
AU  - Shumiya S
FAU - Nagase, S
AU  - Nagase S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Jikken Dobutsu
JT  - Jikken dobutsu. Experimental animals
JID - 1256412
RN  - 0 (Blood Proteins)
RN  - 0 (Glycoproteins)
RN  - 0 (Immunoglobulin M)
RN  - 0 (Serum Albumin)
RN  - 0 (Transferrin)
RN  - 0 (alpha 1-Antitrypsin)
RN  - 0 (alpha-Macroglobulins)
RN  - EC 1.16.3.1 (Ceruloplasmin)
SB  - IM
MH  - *Aging
MH  - Animals
MH  - Blood Proteins/*analysis
MH  - Ceruloplasmin/analysis
MH  - Female
MH  - Glycoproteins/blood
MH  - Immunoglobulin M/analysis
MH  - Male
MH  - Rats
MH  - Rats, Mutant Strains/*blood
MH  - Serum Albumin/analysis/*deficiency
MH  - Transferrin/analysis
MH  - alpha 1-Antitrypsin/analysis
MH  - alpha-Macroglobulins/analysis
EDAT- 1983/07/01 00:00
MHDA- 1983/07/01 00:01
CRDT- 1983/07/01 00:00
PHST- 1983/07/01 00:00 [pubmed]
PHST- 1983/07/01 00:01 [medline]
PHST- 1983/07/01 00:00 [entrez]
AID - 10.1538/expanim1978.32.3_123 [doi]
PST - ppublish
SO  - Jikken Dobutsu. 1983 Jul;32(3):123-32. doi: 10.1538/expanim1978.32.3_123.