PMID- 6197897
OWN - NLM
STAT- MEDLINE
DCOM- 19840224
LR  - 20190908
IS  - 0387-7604 (Print)
IS  - 0387-7604 (Linking)
VI  - 5
IP  - 5
DP  - 1983
TI  - Biochemical analysis of cerebrum of fetal rat X-irradiated in utero--DNA, RNA, 
      superoxide dismutase and lipid peroxide--.
PG  - 457-63
AB  - Wistar rats were X-irradiated in utero and biochemical analysis of the cerebrum 
      was performed on gestational day (g d) 21. The cerebral weight was significantly 
      lower in the irradiated group on g d 13 with above 75R than in the control group. 
      The contents of DNA, RNA and protein were decreased in the cerebrum of the 
      fetuses irradiated with 100R on g d 13 when calculated per cerebrum, and DNA only 
      was decreased occasionally when expressed as per gm wet weight. The lipid 
      peroxide level of the cerebrum in the irradiated group was increased compared to 
      that of the control group. The superoxide dismutase (SOD; E.C. 1.15.1.1.) 
      activity was extremely low and lipid peroxidation in vitro was considerably 
      enhanced in fetal cerebrum. The low activity of SOD may be one of the factors 
      which cause the vulnerability of fetal brain to irradiation.
FAU - Sakuraba, H
AU  - Sakuraba H
FAU - Tanaka, H
AU  - Tanaka H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Dev
JT  - Brain & development
JID - 7909235
RN  - 0 (Lipid Peroxides)
RN  - 63231-63-0 (RNA)
RN  - 9007-49-2 (DNA)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
SB  - IM
MH  - Animals
MH  - Brain/embryology/enzymology
MH  - Brain Chemistry/*radiation effects
MH  - DNA/*radiation effects
MH  - Female
MH  - Fetus/*radiation effects
MH  - Lipid Peroxides/*radiation effects
MH  - Pregnancy
MH  - RNA/*radiation effects
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Superoxide Dismutase/*radiation effects
EDAT- 1983/01/01 00:00
MHDA- 1983/01/01 00:01
CRDT- 1983/01/01 00:00
PHST- 1983/01/01 00:00 [pubmed]
PHST- 1983/01/01 00:01 [medline]
PHST- 1983/01/01 00:00 [entrez]
AID - S0387-7604(83)80074-6 [pii]
AID - 10.1016/s0387-7604(83)80074-6 [doi]
PST - ppublish
SO  - Brain Dev. 1983;5(5):457-63. doi: 10.1016/s0387-7604(83)80074-6.