PMID- 6199030
OWN - NLM
STAT- MEDLINE
DCOM- 19840308
LR  - 20190718
IS  - 0004-3591 (Print)
IS  - 0004-3591 (Linking)
VI  - 27
IP  - 2
DP  - 1984 Feb
TI  - Multiple serologic reactions and their relationship to clinical activity in 
      systemic lupus erythematosus.
PG  - 132-8
AB  - Analysis of the binding of serum from 56 systemic lupus erythematosus patients to 
      native DNA (nDNA), denatured DNA (dDNA), poly I, poly(dT), RNA, and cardiolipin 
      revealed multiple antigen binding in many of the sera. Raised levels of 
      antibodies (IgG and/or IgM) to denatured DNA were found in the highest percentage 
      (68%) of patients. A small subset of patients with multiple raised IgM 
      antibodies, renal disease, and vasculitic skin rash was identified. No 
      correlation between multiple serologic activity and clinical disease was found.
FAU - Isenberg, D A
AU  - Isenberg DA
FAU - Shoenfeld, Y
AU  - Shoenfeld Y
FAU - Schwartz, R S
AU  - Schwartz RS
LA  - eng
GR  - AM 31151/AM/NIADDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Arthritis Rheum
JT  - Arthritis and rheumatism
JID - 0370605
RN  - 0 (Autoantibodies)
RN  - 0 (Cardiolipins)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulin M)
RN  - 25086-81-1 (Poly T)
RN  - 25249-22-3 (Poly I)
RN  - 63231-63-0 (RNA)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Antigen-Antibody Reactions
MH  - Autoantibodies/*analysis
MH  - Cardiolipins/immunology
MH  - Child
MH  - DNA/immunology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Immunoglobulin G/analysis
MH  - Immunoglobulin M/analysis
MH  - Lupus Erythematosus, Systemic/blood/*immunology
MH  - Male
MH  - Middle Aged
MH  - Nucleic Acid Denaturation
MH  - Poly I/immunology
MH  - Poly T/immunology
MH  - RNA/immunology
EDAT- 1984/02/01 00:00
MHDA- 1984/02/01 00:01
CRDT- 1984/02/01 00:00
PHST- 1984/02/01 00:00 [pubmed]
PHST- 1984/02/01 00:01 [medline]
PHST- 1984/02/01 00:00 [entrez]
AID - 10.1002/art.1780270203 [doi]
PST - ppublish
SO  - Arthritis Rheum. 1984 Feb;27(2):132-8. doi: 10.1002/art.1780270203.