PMID- 6203783
OWN - NLM
STAT- MEDLINE
DCOM- 19840822
LR  - 20190913
IS  - 0145-305X (Print)
IS  - 0145-305X (Linking)
VI  - 8
IP  - 2
DP  - 1984 Spring
TI  - H-2 hierarchy in the IR-gene controlled responses to hapten-modified mouse serum 
      albumin.
PG  - 425-34
AB  - Five hapten-modified autogenous mouse serum albumins (MSA), TNP11MSA, FITC8MSA, 
      DNP64MSA, DNP5MSA, and PC2MSA, were tested for their ability to induce 
      hapten-specific antibody responses in H-2 congenic mice of the H2d, H-2b, H-2a, 
      and H-2f haplotypes. Four of the five modified MSAs, TNP11MSA, FITC8MSA, 
      DNP64MSA, and PC2MSA, stimulated responses found to be under H-2-linked Ir gene 
      control, whereas DNP5MSA failed to induce responses in any strain tested. H-2d, 
      H-2D, and H-2a mice responded to FITC8MSA; H-2d and H-2b responded to TNP11MSA; 
      and only H-2d mice were high responders to DNP64MSA and PC2MSA. H-2f mice failed 
      to respond to any of the stimulating antigens. Thus, a hierarchy of H-2 
      haplotypes was observed in the responsiveness to modified MSA with H-2d greater 
      than H-2b greater than H-2a greater than H-2f. Primed lymph node cells from 
      PC2MSA immunized H-2d mice were challenged with antigen in vitro to assess the 
      nature of the determinant recognized by T cells in the response to modified MSA. 
      Lymph node cells proliferated only when challenged with PC2MSA. Unmodified MSA or 
      TNP11MSA did not stimulate a proliferative response, suggesting that the immune T 
      cells recognize a neodeterminant present on the modified PC2MSA.
FAU - Wicker, L S
AU  - Wicker LS
FAU - Kenny, J J
AU  - Kenny JJ
FAU - Urba, W J
AU  - Urba WJ
FAU - Hildemann, W H
AU  - Hildemann WH
LA  - eng
GR  - AI-17760/AI/NIAID NIH HHS/United States
GR  - AI-19470/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Dev Comp Immunol
JT  - Developmental and comparative immunology
JID - 7708205
RN  - 0 (Epitopes)
RN  - 0 (H-2 Antigens)
RN  - 0 (Haptens)
RN  - 0 (Serum Albumin)
SB  - IM
MH  - Animals
MH  - Epitopes/*immunology
MH  - *Genes, MHC Class II
MH  - H-2 Antigens/genetics/*immunology
MH  - Haptens/*immunology
MH  - Lymph Nodes/cytology
MH  - Lymphocyte Activation
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Serum Albumin/*immunology
MH  - T-Lymphocytes/immunology
EDAT- 1984/01/01 00:00
MHDA- 1984/01/01 00:01
CRDT- 1984/01/01 00:00
PHST- 1984/01/01 00:00 [pubmed]
PHST- 1984/01/01 00:01 [medline]
PHST- 1984/01/01 00:00 [entrez]
AID - 0145-305X(84)90049-1 [pii]
AID - 10.1016/0145-305x(84)90049-1 [doi]
PST - ppublish
SO  - Dev Comp Immunol. 1984 Spring;8(2):425-34. doi: 10.1016/0145-305x(84)90049-1.