PMID- 6215662
OWN - NLM
STAT- MEDLINE
DCOM- 19821218
LR  - 20131121
IS  - 0369-9463 (Print)
IS  - 0369-9463 (Linking)
VI  - 31
IP  - 4
DP  - 1982
TI  - Effect of etiroxate on LCAT activity and on certain energy metabolism enzymes in 
      the rat.
PG  - 323-7
AB  - Etiroxate (Skleronorm Grunenthal R) was administered 42 days to male Wistar rats 
      and their serum and liver cholesterol and triglyceride levels, the rate of 
      esterification of free cholesterol in their plasma by lecithin cholesterol 
      acyltransferase (LCAT) (EC 2.3.1.43) and thriosephosphate dehydrogenase (TPDH) 
      (EC 1.2.1.12), lactate dehydrogenase (LDH) (EC 1.1.1.27), hexokinase (HK) (EC 
      2.7.1.1), c-glycerol-3-phosphate dehydrogenase (GPDH) (EC 1.1.1.8), malate 
      dehydrogenase (MDH) (EC 1.1.1.37) citrate synthase (CS) (EC 4.1.3.7) and 
      hydroxyacylcoenzyme A dehydrogenase (HOADH) (EC 1.1.1.35) activity were 
      determined in their liver. After 14 and 28 days, animals given etiroxate (600 
      micrograms/kg) had smaller weight increments than the controls and a 
      significantly lower plasma free and esterified cholesterol level, but a 
      significantly higher liver cholesterol concentration. Their final plasma and 
      liver cholesterol concentrations did not differ significantly from the control 
      values. Plasma triglyceride levels were significantly raised in treated animals 
      at all the given intervals. LCAT activity was significantly higher throughout the 
      whole time of treatment, with the maximum increase in the last phase. Glycolytic 
      and oxidative enzyme activities were significantly raised, whereas GPDH activity 
      was the same as in the controls. The results show that etiroxate accelerates 
      cholesterol turnover in the endogenous pool by activating LCAT and stimulating 
      energy metabolism.
FAU - Dobiasova, M
AU  - Dobiasova M
FAU - Vitek, V
AU  - Vitek V
FAU - Kopecka, J
AU  - Kopecka J
LA  - eng
PT  - Journal Article
PL  - Czech Republic
TA  - Physiol Bohemoslov
JT  - Physiologia Bohemoslovaca
JID - 0175317
RN  - 0S3LDN5P7H (etiroxate)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - EC 2.3.1.43 (Phosphatidylcholine-Sterol O-Acyltransferase)
RN  - Q51BO43MG4 (Thyroxine)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Cholesterol/blood
MH  - *Energy Metabolism
MH  - Male
MH  - Phosphatidylcholine-Sterol O-Acyltransferase/*metabolism
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Thyroxine/*analogs & derivatives/pharmacology
EDAT- 1982/01/01 00:00
MHDA- 1982/01/01 00:01
CRDT- 1982/01/01 00:00
PHST- 1982/01/01 00:00 [pubmed]
PHST- 1982/01/01 00:01 [medline]
PHST- 1982/01/01 00:00 [entrez]
PST - ppublish
SO  - Physiol Bohemoslov. 1982;31(4):323-7.