PMID- 6219899
OWN - NLM
STAT- MEDLINE
DCOM- 19830505
LR  - 20170920
IS  - 0015-0282 (Print)
IS  - 0015-0282 (Linking)
VI  - 39
IP  - 4
DP  - 1983 Apr
TI  - Mixed lymphocyte reactivity nonresponsiveness in couples with multiple 
      spontaneous abortions.
PG  - 525-9
AB  - We have endeavored to ascertain the possible existence of deviant recognition of 
      antigens controlled by the major histocompatibility complex by lymphocytes 
      originating in couples with a history of multiple spontaneous abortions of 
      unknown cause. Human leukocyte antigen (HLA) typing, as well as one-way mixed 
      lymphocyte culture (MLC) tests, were performed on 33 couples with multiple 
      spontaneous abortions and subsequently compared to 30 fertile couples with no 
      abortion history. No significant differences in the frequency of HLA were 
      detected between the fertile and infertile groups. The frequencies of shared 
      HLA-A and -B antigens among members of the couples were similar in both groups. 
      In 70% of the cases studied, the husbands revealed a depressed cellular response 
      to their respective wives; whereas reactivity to cells from other women proved 
      normal. However, the response of allogeneic controls to these infertile women was 
      normal. This implies that women with multiple abortions are not poor stimulators. 
      The specific one-way decrease in the MLC reactivity appeared to be mediated by 
      female-derived suppressor mechanisms and may be considered as one of the causes 
      of the interrupted development of pregnancy in vivo.
FAU - Oksenberg, J R
AU  - Oksenberg JR
FAU - Persitz, E
AU  - Persitz E
FAU - Amar, A
AU  - Amar A
FAU - Schenker, J
AU  - Schenker J
FAU - Segal, S
AU  - Segal S
FAU - Nelken, D
AU  - Nelken D
FAU - Brautbar, C
AU  - Brautbar C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Fertil Steril
JT  - Fertility and sterility
JID - 0372772
RN  - 0 (HLA Antigens)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Abortion, Habitual/*immunology
MH  - Female
MH  - HLA Antigens/*analysis
MH  - Histocompatibility Antigens Class II/analysis
MH  - Humans
MH  - Lymphocyte Culture Test, Mixed
MH  - Lymphocytes/*immunology
MH  - Male
MH  - Pregnancy
EDAT- 1983/04/01 00:00
MHDA- 1983/04/01 00:01
CRDT- 1983/04/01 00:00
PHST- 1983/04/01 00:00 [pubmed]
PHST- 1983/04/01 00:01 [medline]
PHST- 1983/04/01 00:00 [entrez]
AID - S0015-0282(16)46945-1 [pii]
PST - ppublish
SO  - Fertil Steril. 1983 Apr;39(4):525-9.