PMID- 6219919
OWN - NLM
STAT- MEDLINE
DCOM- 19830505
LR  - 20190707
IS  - 0378-1119 (Print)
IS  - 0378-1119 (Linking)
VI  - 20
IP  - 3
DP  - 1982 Dec
TI  - HLA cosmid clones show complete, widely spaced human class I genes with 
      occasional clusters.
PG  - 485-9
AB  - To understand the organization of the human leukocyte antigen (HLA) gene region 
      and its relationship to the transplantation antigens expressed at the cell 
      surface we have isolated clones containing HLA class I genes from a cosmid 
      library (Grosveld et al., Gene 13, 227, 1981) constructed with the DNA from an 
      individual of defined haplotype. Most of the cosmids contain a single HLA gene in 
      30-40 kb of human DNA, indicating that human class I genes are rather widely 
      spaced; two contain two genes and one contains three. Most of these genes appear 
      to be complete; the double or multiple genes are found in the same orientation. 
      Differences in restriction maps are evident but some common features are observed 
      in particular in the 5' half of these genes.
FAU - Malissen, M
AU  - Malissen M
FAU - Damotte, M
AU  - Damotte M
FAU - Birnbaum, D
AU  - Birnbaum D
FAU - Trucy, J
AU  - Trucy J
FAU - Jordan, B R
AU  - Jordan BR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Gene
JT  - Gene
JID - 7706761
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Bacteriophage lambda/genetics
MH  - Chromosome Mapping
MH  - Cloning, Molecular
MH  - Genes, MHC Class II
MH  - Genetic Linkage
MH  - HLA Antigens/*genetics
MH  - Humans
MH  - Repetitive Sequences, Nucleic Acid
EDAT- 1982/12/01 00:00
MHDA- 1982/12/01 00:01
CRDT- 1982/12/01 00:00
PHST- 1982/12/01 00:00 [pubmed]
PHST- 1982/12/01 00:01 [medline]
PHST- 1982/12/01 00:00 [entrez]
AID - 0378-1119(82)90219-0 [pii]
AID - 10.1016/0378-1119(82)90219-0 [doi]
PST - ppublish
SO  - Gene. 1982 Dec;20(3):485-9. doi: 10.1016/0378-1119(82)90219-0.