PMID- 6220731
OWN - NLM
STAT- MEDLINE
DCOM- 19830610
LR  - 20181113
IS  - 0007-1021 (Print)
IS  - 0007-1021 (Linking)
VI  - 64
IP  - 1
DP  - 1983 Feb
TI  - Failure of macrophage activation to induce pulmonary fibrosis in asbestos-exposed 
      guinea-pigs.
PG  - 66-74
AB  - Inhalation of asbestos by specific-pathogen-free (SPF) guinea-pigs the 
      macrophages of which were systemically activated with Freund's complete adjuvant 
      and/or M. tuberculosis (Strain H37Ra) induced a diffuse pulmonary 
      mononuclear-cell infiltration of the interstitium and air space. The severity of 
      the reactions to the various insults was dependent on the treatment given. 
      Although there was no histological evidence of increased collagen, there was a 
      diffuse increase in reticulin in animals which were exposed to asbestos and the 
      macrophages of which were activated. However, even in the case where severe 
      pulmonary inflammatory changes occurred complete resolution of the response took 
      place within 1 year. Therefore in this model activation of macrophages does not 
      have a detrimental effect after inhalation of asbestos.
FAU - Emerson, R J
AU  - Emerson RJ
FAU - Cole, P J
AU  - Cole PJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Br J Exp Pathol
JT  - British journal of experimental pathology
JID - 0372543
RN  - 1332-21-4 (Asbestos)
SB  - IM
MH  - Animals
MH  - Asbestos/*toxicity
MH  - Female
MH  - Guinea Pigs
MH  - Lung/pathology
MH  - *Macrophage Activation
MH  - Macrophages/pathology
MH  - Pneumonia/etiology/immunology/pathology
MH  - Pulmonary Fibrosis/*etiology/immunology
MH  - Specific Pathogen-Free Organisms
PMC - PMC2040774
EDAT- 1983/02/01 00:00
MHDA- 1983/02/01 00:01
PMCR- 1983/02/01
CRDT- 1983/02/01 00:00
PHST- 1983/02/01 00:00 [pubmed]
PHST- 1983/02/01 00:01 [medline]
PHST- 1983/02/01 00:00 [entrez]
PHST- 1983/02/01 00:00 [pmc-release]
PST - ppublish
SO  - Br J Exp Pathol. 1983 Feb;64(1):66-74.