PMID- 62275
OWN - NLM
STAT- MEDLINE
DCOM- 19761230
LR  - 20190902
IS  - 0098-1532 (Print)
IS  - 0098-1532 (Linking)
VI  - 2
IP  - 3
DP  - 1976
TI  - A new hamster fibrosarcoma model for in vitro/in vivo evaluation of cancer 
      chemotherapeutic agents.
PG  - 271-8
AB  - A hamster fetal cell clone has been developed for in vitro chemotherapeutic 
      studies as well as in an in vivo fibrosarcoma model system. Highly reproducible 
      quantitative in vitro chemotherapeutic data can be obtained with this cell line 
      within 5 days, and as few as 10(2) cells produce rapidly growing fibrosarcomas 
      when injected subcutaneously into adult hamsters. We found using these cells in 
      vitro that 1-beta-D-arabinofuranosylcytosine (ara-C) can antagonize the effect of 
      5-azacytidine (aza-C) if given simultaneously or if aza-C treatment is preceded 
      by a 2-hr exposure to ara-c. Using the same cell line as in vivo model for 
      chemotherapy it was also shown that ara-C and cyclocytidine significantly 
      inhibited tumor growth. This hamster cell line may be quite useful as an in 
      vitro/in vivo model system for the study of cancer chemotherapeutic agents.
FAU - Benedict, W F
AU  - Benedict WF
FAU - Khwaja, T A
AU  - Khwaja TA
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Med Pediatr Oncol
JT  - Medical and pediatric oncology
JID - 7506654
RN  - 0 (Antineoplastic Agents)
RN  - 04079A1RDZ (Cytarabine)
RN  - DO2D32W0VC (Ancitabine)
RN  - M801H13NRU (Azacitidine)
SB  - IM
MH  - Ancitabine/therapeutic use
MH  - Animals
MH  - Antineoplastic Agents/*therapeutic use
MH  - Azacitidine/therapeutic use
MH  - Cell Division
MH  - Cell Line
MH  - Cells, Cultured
MH  - Clone Cells
MH  - Cricetinae
MH  - Cytarabine/therapeutic use
MH  - *Disease Models, Animal
MH  - Drug Therapy, Combination
MH  - Female
MH  - Fibrosarcoma/*drug therapy/pathology
MH  - Mesocricetus
MH  - Sarcoma, Experimental/*drug therapy/pathology
EDAT- 1976/01/01 00:00
MHDA- 1976/01/01 00:01
CRDT- 1976/01/01 00:00
PHST- 1976/01/01 00:00 [pubmed]
PHST- 1976/01/01 00:01 [medline]
PHST- 1976/01/01 00:00 [entrez]
AID - 10.1002/mpo.2950020308 [doi]
PST - ppublish
SO  - Med Pediatr Oncol. 1976;2(3):271-8. doi: 10.1002/mpo.2950020308.