PMID- 6233467
OWN - NLM
STAT- MEDLINE
DCOM- 19840725
LR  - 20190701
IS  - 0024-3205 (Print)
IS  - 0024-3205 (Linking)
VI  - 34
IP  - 25
DP  - 1984 Jun 18
TI  - 5-Hydroxytryptamine : a modulator of food composition but not quantity?
PG  - 2453-60
AB  - After a meal of protein, in contrast to a meal of carbohydrate (CHO) at 1915 hr, 
      rats allowed to choose from high carbohydrate and high protein diets during 
      2000-2100 hr prefer CHO (1). Thus the hypothesis that this regulation of 
      macronutrient selection involves brain 5-hydroxytryptamine (5-HT) metabolism was 
      tested. Compared to three baseline days during which rats (250- 300g ) consumed 1 
      g CHO, rats fed tryptophan (TRP, 5-HT precursor; 15 mg in 1 g CHO) selected meals 
      higher in protein concentration (35.4% vs 46.6%, F (1,12) = 20.05, p less than 
      0.001) from 10% and 60% casein diets during 2000-2100 hr. Associated with the 
      higher protein selection was an elevated brain 5-HT turnover in rats killed 30 
      minutes after consuming CHO + TRP. Pretreating rats with p-chlorophenylalanine, 
      an inhibitor of TRP hydroxylase, blocked this effect of TRP (36.3% vs 37.0%). 
      Fenfluramine (1 and 2 mg/kg i.p. at 1945 hr), which transiently enhances neuronal 
      5-HT release, increased the rat's relative preference for protein from 28.8% to 
      37.5% (2 mg/kg, t = 3.21, p less than 0.025) during 2000-2100 hr. These rats, 
      also exhibited a selective preference for CHO between 3-12 hrs post injection 
      which paralleled the known subsequent depletion of 5-HT by fenfluramine. We 
      conclude that the relative proportion of protein and carbohydrate selected in a 
      meal is controlled, at least in part, by prior food effects on brain 5-HT 
      metabolism.
FAU - Li, E T
AU  - Li ET
FAU - Anderson, G H
AU  - Anderson GH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Proteins)
RN  - 2DS058H2CF (Fenfluramine)
RN  - 333DO1RDJY (Serotonin)
RN  - 8DUH1N11BX (Tryptophan)
RN  - R5J7E3L9SP (Fenclonine)
SB  - IM
MH  - Animals
MH  - Brain Chemistry/drug effects
MH  - *Dietary Carbohydrates
MH  - *Dietary Proteins
MH  - Fenclonine/pharmacology
MH  - Fenfluramine/pharmacology
MH  - *Food Preferences
MH  - Male
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Serotonin/analysis/*physiology
MH  - Tryptophan/pharmacology
EDAT- 1984/06/18 00:00
MHDA- 1984/06/18 00:01
CRDT- 1984/06/18 00:00
PHST- 1984/06/18 00:00 [pubmed]
PHST- 1984/06/18 00:01 [medline]
PHST- 1984/06/18 00:00 [entrez]
AID - 0024-3205(84)90281-9 [pii]
AID - 10.1016/0024-3205(84)90281-9 [doi]
PST - ppublish
SO  - Life Sci. 1984 Jun 18;34(25):2453-60. doi: 10.1016/0024-3205(84)90281-9.