PMID- 6235938
OWN - NLM
STAT- MEDLINE
DCOM- 19841025
LR  - 20190825
IS  - 0009-2797 (Print)
IS  - 0009-2797 (Linking)
VI  - 51
IP  - 2
DP  - 1984 Sep 15
TI  - Effect of molybdenum on the acute toxicity of mercuric chloride. IV. Effect of 
      molybdenum on mercury-mediated metallothionein mRNA induction.
PG  - 219-31
AB  - In order to elucidate the mechanism of the stimulative effect of molybdenum on 
      mercury-mediated renal metallothionein induction, the levels of translatable 
      metallothionein mRNA (MT mRNA) in the kidneys of rats treated with saline or 
      Na2MoO4 or HgCl2 or Na2MoO4 and HgCl2 were measured by translation experiments in 
      cell-free protein synthesizing systems. The time course of accumulation of 
      mercury in renal nuclei of rats given HgCl2 with or without Na2MoO4-pretreatment 
      was also investigated. Molybdenum, itself, did not elevate levels of MT mRNA 
      compared to saline controls at all time points (0, 6 and 14 h after exposure to 
      HgCl2) but rapidly elevated the levels of the mRNA more than Hg-dosed rats when 
      HgCl2 was also administered. On the other hand, the time course study in renal 
      nuclei showed that the mercury content of nuclei was consistently lower in 
      Mo-Hg-dosed rats than in Hg-dosed rats at all time points (4, 8 and 24 h after 
      exposure to HgCl2). These results suggest that the stimulative effect of 
      molybdenum on mercury-mediated metallothionein induction is coupled with an 
      increase of the mRNA coding for the low molecular weight protein and that such an 
      increase in the levels of translatable MT mRNA is not due to the difference in 
      uptake of mercury into renal nuclei.
FAU - Koizumi, T
AU  - Koizumi T
FAU - Saito, S
AU  - Saito S
FAU - Yamane, Y
AU  - Yamane Y
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - Chem Biol Interact
JT  - Chemico-biological interactions
JID - 0227276
RN  - 0 (Chlorides)
RN  - 0 (RNA, Messenger)
RN  - 53GH7MZT1R (Mercuric Chloride)
RN  - 81AH48963U (Molybdenum)
RN  - 9038-94-2 (Metallothionein)
RN  - 948QAQ08I1 (sodium molybdate(VI))
RN  - FXS1BY2PGL (Mercury)
RN  - K848JZ4886 (Cysteine)
SB  - IM
MH  - Animals
MH  - Cell-Free System
MH  - Chlorides/*pharmacology/toxicity
MH  - Cysteine/metabolism
MH  - Drug Interactions
MH  - Kidney/metabolism
MH  - Male
MH  - Mercuric Chloride
MH  - Mercury/*pharmacology/toxicity
MH  - Metallothionein/*biosynthesis/genetics
MH  - Mitochondria/metabolism
MH  - Molybdenum/*pharmacology
MH  - RNA, Messenger/*metabolism
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Triticum
EDAT- 1984/09/15 00:00
MHDA- 1984/09/15 00:01
CRDT- 1984/09/15 00:00
PHST- 1984/09/15 00:00 [pubmed]
PHST- 1984/09/15 00:01 [medline]
PHST- 1984/09/15 00:00 [entrez]
AID - 0009-2797(84)90031-0 [pii]
AID - 10.1016/0009-2797(84)90031-0 [doi]
PST - ppublish
SO  - Chem Biol Interact. 1984 Sep 15;51(2):219-31. doi: 10.1016/0009-2797(84)90031-0.