PMID- 6237567
OWN - NLM
STAT- MEDLINE
DCOM- 19841102
LR  - 20190626
IS  - 0002-8703 (Print)
IS  - 0002-8703 (Linking)
VI  - 108
IP  - 4 Pt 1
DP  - 1984 Oct
TI  - A new approach to quantitation of exercise thallium-201 scintigraphy before and 
      after an intervention: application to define the impact of coronary angioplasty 
      on regional myocardial perfusion.
PG  - 917-25
AB  - We have developed a new computer method designed to quantitate regional 
      myocardial thallium-201 (TI-201) initial distribution, redistribution, and 
      clearance rate. In addition, this computer method permits the generation of 
      functional images to compare two thallium images in the same projection to one 
      another. These functional images can be used to demonstrate the extent of 
      redistribution and the extent of change in regional perfusion before and after an 
      intervention. To validate and apply this new computer technique, exercise TI-201 
      myocardial images obtained before and 1 week after percutaneous transluminal 
      coronary angioplasty (PTCA) were analyzed in 20 patients with isolated left 
      anterior descending coronary artery disease. Significant improvement in initial 
      TI-201 activity, expressed as a percentage of maximal myocardial activity, was 
      present in the anterior (71.9 +/- 12.0 to 84.1 +/- 11.5%, p less than 0.001) and 
      septal (66.7 +/- 15.4 to 75.2 +/- 11.0%, p less than 0.05) regions of the left 
      ventricle 1 week after PTCA. This increase in relative anterior wall TI-201 
      uptake was associated with a significant reduction in the amount of TI-201 
      redistribution between initial and delayed postexercise images (14.7 +/- 14.6 to 
      3.0 +/- 13.2%, p less than 0.05) as well as an increase in TI-201 clearance rate 
      (t 1/2 from 8.8 +/- 4.4 to 4.3 +/- 2.5 hours, p less than 0.001). Quantitative 
      analysis of TI-201 scans demonstrated improvement in 14 of 20 patients following 
      PTCA. Computer-derived functional difference images depicted diminution in the 
      extent of ischemia as manifested by redistribution of TI-201.(ABSTRACT TRUNCATED 
      AT 250 WORDS)
FAU - Lim, Y L
AU  - Lim YL
FAU - Okada, R D
AU  - Okada RD
FAU - Chesler, D A
AU  - Chesler DA
FAU - Block, P C
AU  - Block PC
FAU - Boucher, C A
AU  - Boucher CA
FAU - Pohost, G M
AU  - Pohost GM
LA  - eng
GR  - HL-21751/HL/NHLBI NIH HHS/United States
GR  - HL-26215/HL/NHLBI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am Heart J
JT  - American heart journal
JID - 0370465
RN  - 0 (Radioisotopes)
RN  - AD84R52XLF (Thallium)
SB  - IM
MH  - Adult
MH  - *Angioplasty, Balloon
MH  - Computers
MH  - *Coronary Circulation
MH  - Coronary Disease/diagnostic imaging/physiopathology/*therapy
MH  - *Exercise Test
MH  - Female
MH  - Heart/*diagnostic imaging
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Radioisotopes
MH  - Radionuclide Imaging
MH  - Thallium
EDAT- 1984/10/01 00:00
MHDA- 1984/10/01 00:01
CRDT- 1984/10/01 00:00
PHST- 1984/10/01 00:00 [pubmed]
PHST- 1984/10/01 00:01 [medline]
PHST- 1984/10/01 00:00 [entrez]
AID - 0002-8703(84)90455-1 [pii]
AID - 10.1016/0002-8703(84)90455-1 [doi]
PST - ppublish
SO  - Am Heart J. 1984 Oct;108(4 Pt 1):917-25. doi: 10.1016/0002-8703(84)90455-1.