PMID- 6237981
OWN - NLM
STAT- MEDLINE
DCOM- 19841128
LR  - 20181113
IS  - 0019-2805 (Print)
IS  - 1365-2567 (Electronic)
IS  - 0019-2805 (Linking)
VI  - 53
IP  - 2
DP  - 1984 Oct
TI  - One-way occurrence of graft-versus-host disease in bone marrow chimaeras between 
      congenic MRL mice.
PG  - 251-6
AB  - Bone marrow cells (BMCs) of MRL/Mp-lpr/lpr (MRL/l) mice, when infused into 
      irradiated MRL/Mp-+/+ (MRL/n) mice, induced graft-versus-host disease (GVHD) and 
      recipients died of wasting syndromes beginning around a few weeks later. 
      Protracted appearance of GVHD was observed when (MRL/n X MRL/l) F1 mice were used 
      as recipients of MRL/l BMSs. On the other hand, MRL/n BMCs did not elicit GVHD in 
      irradiated MRL/l mice. Treatment of MRL/l BMCs with anti-Thy-l antiserum plus 
      complement did not eliminate GVHD-provoking capacity. Thymectomy of the recipents 
      reduced the incidence of GVHD. No apparent reaction was observed in mutual mixed 
      lymphocyte culture of spleen cells from MRL/l and MRL/n mice. These data suggest 
      that injected T cell precursors of MRL/l mice become mature through the host 
      (MRL/n mice) thymus and appear in the periphery as functioning T cells, resulting 
      in the appearance of GVHD.
FAU - Fujiwara, M
AU  - Fujiwara M
FAU - Kariyone, A
AU  - Kariyone A
LA  - eng
PT  - Journal Article
PL  - England
TA  - Immunology
JT  - Immunology
JID - 0374672
SB  - IM
MH  - Animals
MH  - *Bone Marrow Transplantation
MH  - Graft vs Host Disease/*etiology/immunology/mortality/pathology
MH  - Lymphocyte Culture Test, Mixed
MH  - Mice
MH  - Mice, Inbred Strains
MH  - *Radiation Chimera
MH  - Spleen/pathology
MH  - Thymectomy
PMC - PMC1454822
EDAT- 1984/10/01 00:00
MHDA- 1984/10/01 00:01
PMCR- 1985/10/01
CRDT- 1984/10/01 00:00
PHST- 1984/10/01 00:00 [pubmed]
PHST- 1984/10/01 00:01 [medline]
PHST- 1984/10/01 00:00 [entrez]
PHST- 1985/10/01 00:00 [pmc-release]
PST - ppublish
SO  - Immunology. 1984 Oct;53(2):251-6.