PMID- 6242346
OWN - NLM
STAT- MEDLINE
DCOM- 19851029
LR  - 20141120
IS  - 0301-0457 (Print)
IS  - 0301-0457 (Linking)
IP  - 72
DP  - 1983 May
TI  - Autorosette forming cells: phenotypic analysis, specificity and role in the 
      autologous mixed lymphocyte reaction.
PG  - 89-94
AB  - The phenotype of autorosette forming cells (A-RFC) in the peripheral blood of 
      normal subjects was analyzed. Using a fluorescent technique in which the 
      rosetting cells are labeled with different monoclonal antibodies directed against 
      various cell surface antigens, we demonstrated that A-RFC are T cells, the 
      majority of which belong to the helper/inducer subset. Nevertheless, about 10% of 
      the A-RFC bear the Leu 2a antigens, which are specific for cytotoxic/suppressor T 
      cells. On the other hand, no autorosettes were identified by OKT6 or anti-DR 
      antibodies. When autologous and allogeneic red blood cells were added 
      simultaneously to lymphocytes, 78% mixed rosettes were formed, suggesting a lack 
      of specificity in autorosette formation. A functional role for A-RFC in the 
      autologous mixed lymphocyte reaction (A-MLR) is demonstrated by the fact that the 
      removal of A-RFC from the responder population abrogated the proliferative 
      response in A-MLR. Therefore, despite their non restriction, A-RFC may represent 
      an autoreactive T cell subset.
FAU - Fournier, C
AU  - Fournier C
FAU - Nalet, V
AU  - Nalet V
FAU - Charreire, J
AU  - Charreire J
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Behring Inst Mitt
JT  - Behring Institute Mitteilungen
JID - 0367532
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Autoantigens)
RN  - 0 (Isoantigens)
SB  - IM
MH  - Antibodies, Monoclonal/immunology
MH  - Autoantigens/immunology
MH  - Erythrocytes/immunology
MH  - Humans
MH  - In Vitro Techniques
MH  - Isoantigens/immunology
MH  - Lymphocyte Activation
MH  - *Lymphocyte Culture Test, Mixed
MH  - *Rosette Formation
MH  - T-Lymphocytes/classification/*immunology
EDAT- 1983/05/01 00:00
MHDA- 1983/05/01 00:01
CRDT- 1983/05/01 00:00
PHST- 1983/05/01 00:00 [pubmed]
PHST- 1983/05/01 00:01 [medline]
PHST- 1983/05/01 00:00 [entrez]
PST - ppublish
SO  - Behring Inst Mitt. 1983 May;(72):89-94.