PMID- 6244324
OWN - NLM
STAT- MEDLINE
DCOM- 19800530
LR  - 20151119
IS  - 0021-972X (Print)
IS  - 0021-972X (Linking)
VI  - 50
IP  - 3
DP  - 1980 Mar
TI  - Adenosine 3',5'-monophosphate response to parathyroid hormone: familial 
      hypocalciuric hypercalcemia versus typical primary hyperparathyroidism.
PG  - 546-8
AB  - We investigated cAMP metabolism during and after a 15-min infusion of parathyroid 
      hormone (PTH) in 7 normals, 13 patients with typical primary hyperparathyroidism 
      (1HPT), and 6 patients with familial hypocalciuric hypercalcemia (FHH). 
      Nephrogenous urinary cAMP excretion rate reached a peak during the first or 
      second 30 min urine collection interval after the start of the PTH infusion in 
      all subjects. cAMP concentration in plasma reached a peak within 5--20 min of the 
      start of the infusion and then decreased with an initial half-time of 15 min. The 
      peak value of nephrogenous urinary cAMP excretion rate was lower in the group 
      with 1HPT than in the group with FHH or in normals (119 vs, 275 vs. 204 nmol/100 
      ml glomerular filtrate; P less than 0.0 5 for both comparisons). Similarly, the 
      peak value of plasma cAMP concentration was less in 1HPT subjects than in FHH 
      patients or in normals (11.1 vs. 17.1 vs. 16.6 nmol/100 ml, respectively; P less 
      than 0.05 for both comparisons). For purposes of diagnostic classification, the 
      two hypercalcemia groups could be more completely separated by the values of 
      either the renal calcium to creatinine clearance ratio or the plasma PTH 
      concentration than by the values of inidices of cAMP response to PTH. The 
      differences in cAMP response to PTH between FHH and 1HPT patients could be 
      secondary to differences in circulating PTH concentrations (these are lower in 
      subjects with FHH) or could reflect a renal lesion more closely related to the 
      underlying etiology of FHH.
FAU - Marx, S J
AU  - Marx SJ
FAU - Spiegel, A M
AU  - Spiegel AM
FAU - Sharp, M E
AU  - Sharp ME
FAU - Brown, E M
AU  - Brown EM
FAU - Gardner, D G
AU  - Gardner DG
FAU - Downs, R W Jr
AU  - Downs RW Jr
FAU - Attie, M F
AU  - Attie MF
FAU - Stock, J L
AU  - Stock JL
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (Parathyroid Hormone)
RN  - E0399OZS9N (Cyclic AMP)
SB  - IM
MH  - Cyclic AMP/blood/*metabolism/urine
MH  - Female
MH  - Humans
MH  - Hypercalcemia/*genetics/metabolism
MH  - Hyperparathyroidism/*metabolism
MH  - Male
MH  - *Parathyroid Hormone
MH  - Time Factors
EDAT- 1980/03/01 00:00
MHDA- 2001/03/28 10:01
CRDT- 1980/03/01 00:00
PHST- 1980/03/01 00:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1980/03/01 00:00 [entrez]
AID - 10.1210/jcem-50-3-546 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 1980 Mar;50(3):546-8. doi: 10.1210/jcem-50-3-546.