PMID- 6246012
OWN - NLM
STAT- MEDLINE
DCOM- 19800728
LR  - 20190708
IS  - 0020-7136 (Print)
IS  - 0020-7136 (Linking)
VI  - 25
IP  - 5
DP  - 1980 May 15
TI  - Isolation of a series of novel variants of murine mammary tumor viruses with 
      broadened host ranges.
PG  - 647-54
AB  - We have previously isolated mouse mammary tumor virus (MMTV) host range variants 
      by serial virus passage in feline cells. These variants productively infect cells 
      of a broad range of species but replicate most efficiently in feline cells. We 
      report here the isolation of a series of novel MMTV host range variants that have 
      the ability to replicate with high efficiency in murine, rat, canine and human 
      cells, respectively; these variants were isolated by serial virus passage in 
      cells of each respective species. These new variants, furthermore, all retained 
      their ability to efficiently replicate in feline cells, and each exhibited unique 
      host range properties. The novel MMTV variants obtained from murine, rat, feline, 
      canine, and human cells showed no overt evidence of recombination with endogenous 
      type-C viruses in that they retained their antigenic reactivities in 
      group-specific radioimmunoassays for MMTV polypeptides, and were unreactive for 
      type-C virus proteins when tested by radioimmunoassays and DNA polymerase assays. 
      These novel MMTV host range variants now broaden the spectrum of studies that can 
      be undertaken involving MMTV replication and the initiation and promotion of 
      virus-mediated mammary cell transformation.
FAU - Howard, D K
AU  - Howard DK
FAU - Schlom, J
AU  - Schlom J
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Int J Cancer
JT  - International journal of cancer
JID - 0042124
RN  - 0 (Antigens, Viral)
RN  - EC 2.7.7.7 (DNA-Directed DNA Polymerase)
SB  - IM
MH  - Animals
MH  - Antigens, Viral/analysis
MH  - Cats
MH  - Cell Line
MH  - DNA-Directed DNA Polymerase/analysis
MH  - Dogs
MH  - Female
MH  - Humans
MH  - Mammary Tumor Virus, Mouse/immunology/*isolation & purification/metabolism
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C3H
MH  - Pregnancy
MH  - Radioimmunoassay
MH  - Rats
MH  - Species Specificity
MH  - Virus Replication
EDAT- 1980/05/15 00:00
MHDA- 1980/05/15 00:01
CRDT- 1980/05/15 00:00
PHST- 1980/05/15 00:00 [pubmed]
PHST- 1980/05/15 00:01 [medline]
PHST- 1980/05/15 00:00 [entrez]
AID - 10.1002/ijc.2910250515 [doi]
PST - ppublish
SO  - Int J Cancer. 1980 May 15;25(5):647-54. doi: 10.1002/ijc.2910250515.