PMID- 6247967
OWN - NLM
STAT- MEDLINE
DCOM- 19800828
LR  - 20210526
IS  - 0066-4804 (Print)
IS  - 1098-6596 (Electronic)
IS  - 0066-4804 (Linking)
VI  - 17
IP  - 2
DP  - 1980 Feb
TI  - In vitro and in vivo resistance of herpes simplex virus to 
      9-(2-hydroxyethoxymethyl)guanine (acycloguanosine).
PG  - 144-50
AB  - In vitro passage of the Patton strain of herpes simplex virus type 1 (HSV-1-P) in 
      the presence of acycloguanosine (ACG) led to the emergence of a highly 
      drug-resistant strain (HSV-1-P-ACG-R). Over 1% of virions in 6 of 15 HSV strains 
      tested were able to form plaques in the presence of 10 mumol of ACG on first 
      exposure to the drug. Therefore, there exists among HSV strains a broad range of 
      susceptibilities to ACG, and some strains contain particles which are partially 
      resistant to ACG before ever contacting the drug. HSV-1-P-ACG-R was partially 
      resistant to iododeoxyuridine; conversely, iododeoxyuridine-resistant virus was 
      highly resistant to ACG. ACG-resistant virus (HSV-1-P-ACG-R) was equal to its 
      parent strain (HSV-1-P) in susceptibility to adenine arabinoside. The 
      HSV-1-P-ACG-R strain produced corneal lesions in rabbits which were completely 
      refractory to topical treatment with 1% unguent ACG, but responsive to 3% ACG. 
      Partially resistant HSV could be isolated from the eyes of rabbits infected with 
      ACG-susceptible virus and treated topically with either 1 or 3% ACG for 6 days.
FAU - Smith, K O
AU  - Smith KO
FAU - Kennell, W L
AU  - Kennell WL
FAU - Poirier, R H
AU  - Poirier RH
FAU - Lynd, F T
AU  - Lynd FT
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Antimicrob Agents Chemother
JT  - Antimicrobial agents and chemotherapy
JID - 0315061
RN  - 0 (Antiviral Agents)
RN  - 5Z93L87A1R (Guanine)
RN  - FA2DM6879K (Vidarabine)
RN  - LGP81V5245 (Idoxuridine)
RN  - X4HES1O11F (Acyclovir)
SB  - IM
MH  - Acyclovir
MH  - Animals
MH  - Antiviral Agents/*pharmacology/therapeutic use
MH  - Cells, Cultured
MH  - Drug Resistance, Microbial
MH  - Guanine/*analogs & derivatives/pharmacology/therapeutic use
MH  - Herpes Simplex/*drug therapy
MH  - Humans
MH  - Idoxuridine/pharmacology
MH  - Keratitis, Dendritic/drug therapy/microbiology
MH  - Rabbits
MH  - Simplexvirus/*drug effects
MH  - Vidarabine/pharmacology
PMC - PMC283749
EDAT- 1980/02/01 00:00
MHDA- 1980/02/01 00:01
PMCR- 1980/02/01
CRDT- 1980/02/01 00:00
PHST- 1980/02/01 00:00 [pubmed]
PHST- 1980/02/01 00:01 [medline]
PHST- 1980/02/01 00:00 [entrez]
PHST- 1980/02/01 00:00 [pmc-release]
AID - 10.1128/AAC.17.2.144 [doi]
PST - ppublish
SO  - Antimicrob Agents Chemother. 1980 Feb;17(2):144-50. doi: 10.1128/AAC.17.2.144.