PMID- 6248600
OWN - NLM
STAT- MEDLINE
DCOM- 19800926
LR  - 20190511
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 141
IP  - 6
DP  - 1980 Jun
TI  - Disease due to enterotoxigenic Escherichia coli in Bangladeshi adults: clinical 
      aspects and a controlled trial of tetracycline.
PG  - 702-11
AB  - The clinical characteristics of disease due to enterotoxigenic Escherichia coli 
      (ETEC) were determined in 88 adult males admitted to a hospital in Dacca, 
      Bangladesh, with moderate to severe dehydration. Persons infected with ETEC 
      strains producing both heat-labile toxin (LT) and heat-stable (ST) toxin had more 
      dehydration and acidosis, longer duration of illness, and greater stool volume 
      than persons infected with strains producing only ST. Tetracycline therapy, 
      evaluated in 63 cases, resulted in slightly earlier termination of illness in 
      patients with LT-ST strains but had no effect on illness in the patients with ST 
      strains. In both groups of patients tetracycline shortened the duration of 
      excretion of organisms. Because of its limited effectiveness and the generally 
      excellent response of ETEC diarrhea to rehydration therapy alone, tetracycline is 
      not warranted for use in treatment of ETEC diarrhea in adults in this population.
FAU - Merson, M H
AU  - Merson MH
FAU - Sack, R B
AU  - Sack RB
FAU - Islam, S
AU  - Islam S
FAU - Saklayen, G
AU  - Saklayen G
FAU - Huda, N
AU  - Huda N
FAU - Huq, I
AU  - Huq I
FAU - Zulich, A W
AU  - Zulich AW
FAU - Yolken, R H
AU  - Yolken RH
FAU - Kapikian, A Z
AU  - Kapikian AZ
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - F8VB5M810T (Tetracycline)
SB  - IM
MH  - Adult
MH  - Bangladesh
MH  - Clinical Trials as Topic
MH  - Diarrhea/drug therapy/*epidemiology/microbiology
MH  - Escherichia coli/classification/*drug effects/pathogenicity
MH  - Escherichia coli Infections/*drug therapy/microbiology/pathology
MH  - Feces/microbiology
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Microbial Sensitivity Tests
MH  - Rotavirus/isolation & purification
MH  - Salmonella/isolation & purification
MH  - Shigella/isolation & purification
MH  - Tetracycline/administration & dosage/*therapeutic use
MH  - Vibrio/isolation & purification
EDAT- 1980/06/01 00:00
MHDA- 1980/06/01 00:01
CRDT- 1980/06/01 00:00
PHST- 1980/06/01 00:00 [pubmed]
PHST- 1980/06/01 00:01 [medline]
PHST- 1980/06/01 00:00 [entrez]
AID - 10.1093/infdis/141.6.702 [doi]
PST - ppublish
SO  - J Infect Dis. 1980 Jun;141(6):702-11. doi: 10.1093/infdis/141.6.702.