PMID- 6249191
OWN - NLM
STAT- MEDLINE
DCOM- 19800928
LR  - 20210526
IS  - 0066-4804 (Print)
IS  - 1098-6596 (Electronic)
IS  - 0066-4804 (Linking)
VI  - 17
IP  - 4
DP  - 1980 Apr
TI  - Combination chemotherapy: interaction of 5-methoxymethyldeoxyuridine with adenine 
      arabinoside, 5-ethyldeoxyuridine, 5-iododeoxyuridine, and phosphonoacetic acid 
      against herpes simplex virus types 1 and 2.
PG  - 558-66
AB  - The antiviral activity of 5-methoxymethyl-2'-deoxyuridine (MMUdR) was compared 
      with that of 5-iodo-2'-deoxyuridine (IUdR), 5-ethyl-2'-deoxyuridine (EtUdR), 
      adenine arabinoside (Ara-A), and phosphonoacetic acid (PAA) against herpes 
      simplex virus type 1 (HSV-1) and type 2 (HSV-2). MMUdR was more potent than Ara-A 
      and PAA but less active than EtUdR and IUdR against HSV-1 in rabbit kidney 
      (RK-13) cells. In Vero cells, the antiviral activities of MMUdR, Ara-A, and PAA 
      against HSV-1 were of the same order of magnitude. The antiviral potency against 
      HSV-2 varied with the strain of virus used. All strains of HSV-2 were markedly 
      inhibited by EtUdR and IUdR and to a lesser degree by PAA. However, considerable 
      variation was noticed in the susceptibility of HSV-2 strains to Ara-A and MMUdR. 
      Interaction of MMUdR with Ara-A, EtUdR, IUdR, and PAA was investigated by the 
      method of response isobolograms. MMUdR showed synergistic activity in combination 
      with Ara-A and PAA but antagonistic activity in combination with EtUdR and IUdR 
      against herpesviruses. Minimum toxic dose (concentration required to produce 
      definite evidence of microscopic cytotoxicity in rapidly growing RK-13 cells) was 
      determined for each compound and was found to be 512, 172, 64, 8, and less than 
      0.5 microgram/ml for MMUdR, PAA, Ara-A, EtUdR, and IUdR, respectively. MMUdR was 
      found to have the maximum antiviral index against HSV-1 (512) and HSV-2 strains 
      X-265 (102) and ATCC (85). Antiviral index was defined as the minimum toxic dose 
      divided by the dose that reduced plaque numbers by 50%.
FAU - Ayisi, N K
AU  - Ayisi NK
FAU - Gupta, V S
AU  - Gupta VS
FAU - Meldrum, J B
AU  - Meldrum JB
FAU - Taneja, A K
AU  - Taneja AK
FAU - Babiuk, L A
AU  - Babiuk LA
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Antimicrob Agents Chemother
JT  - Antimicrobial agents and chemotherapy
JID - 0315061
RN  - 0 (Antiviral Agents)
RN  - 5116-22-3 (5-methoxymethyl-2'-deoxyuridine)
RN  - FA2DM6879K (Vidarabine)
RN  - LGP81V5245 (Idoxuridine)
RN  - N919E46723 (Phosphonoacetic Acid)
RN  - W78I7AY22C (Deoxyuridine)
SB  - IM
MH  - Animals
MH  - Antiviral Agents/administration & dosage/*pharmacology/toxicity
MH  - Deoxyuridine/administration & dosage/*analogs & derivatives/pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Drug Resistance, Microbial
MH  - Drug Synergism
MH  - Drug Therapy, Combination
MH  - Female
MH  - Herpes Simplex/drug therapy
MH  - Idoxuridine/administration & dosage/pharmacology
MH  - Mutation
MH  - Phosphonoacetic Acid/administration & dosage/pharmacology
MH  - Rabbits
MH  - Simplexvirus/*drug effects
MH  - Vidarabine/administration & dosage/pharmacology
PMC - PMC283832
EDAT- 1980/04/01 00:00
MHDA- 1980/04/01 00:01
PMCR- 1980/04/01
CRDT- 1980/04/01 00:00
PHST- 1980/04/01 00:00 [pubmed]
PHST- 1980/04/01 00:01 [medline]
PHST- 1980/04/01 00:00 [entrez]
PHST- 1980/04/01 00:00 [pmc-release]
AID - 10.1128/AAC.17.4.558 [doi]
PST - ppublish
SO  - Antimicrob Agents Chemother. 1980 Apr;17(4):558-66. doi: 10.1128/AAC.17.4.558.