PMID- 6253525
OWN - NLM
STAT- MEDLINE
DCOM- 19810129
LR  - 20181113
IS  - 0021-9738 (Print)
IS  - 0021-9738 (Linking)
VI  - 66
IP  - 5
DP  - 1980 Nov
TI  - Lipoxygenation of arachidonic acid as a source of polymorphonuclear leukocyte 
      chemotactic factors in synovial fluid and tissue in rheumatoid arthritis and 
      spondyloarthritis.
PG  - 1166-70
AB  - The predominant lipoxygenase products of arachidonic acid were extracted and 
      purified from synovial fluid and sonicates of synovial tissue of patients with 
      rheumatoid arthritis (RA), spondyloarthritis (SA), or a noninflammatory 
      arthropathy (NIA). The concentration of 
      5(S),12(R)-dihydroxy-6,8,10-(trans/trans/cis)-14-cis-eicosatetraenoic acid 
      (leukotriene B4) in synovial fluid was elevated significantly in patients with RA 
      and a positive latex test for rheumatoid factor (P < 0.05, n = 14) and in 
      patients with SA (P < 0.05, n = 10), compared with that of subjects with NIA (n = 
      9). The content of 5(S)-hydroxy-6,8,11,14-eicosatetraenoic acid (5-HETE), but not 
      of leukotriene B4, was elevated significantly in synovial tissue of seven 
      patients with RA in comparison with that of four subjects with NIA (P < 0.05). A 
      single intra-articular injection of corticosteroid significantly lowered the 
      synovial fluid level of leukotriene B4 in six patients with RA. These data 
      suggest an involvement of the potent chemotactic factors 5-HETE and leukotriene 
      B4 in human inflammatory disease.
FAU - Klickstein, L B
AU  - Klickstein LB
FAU - Shapleigh, C
AU  - Shapleigh C
FAU - Goetzl, E J
AU  - Goetzl EJ
LA  - eng
GR  - AI-07722/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Clin Invest
JT  - The Journal of clinical investigation
JID - 7802877
RN  - 0 (Arachidonic Acids)
RN  - 0 (Chemotactic Factors)
RN  - 0 (Hydroxyeicosatetraenoic Acids)
RN  - 1HGW4DR56D (Leukotriene B4)
RN  - 467RNW8T91 (5-hydroxy-6,8,11,14-eicosatetraenoic acid)
RN  - EC 1.13.11.12 (Lipoxygenase)
SB  - IM
MH  - Arachidonic Acids/*analysis/*metabolism
MH  - Arthritis, Rheumatoid/*blood
MH  - Chemotactic Factors/*blood
MH  - *Hydroxyeicosatetraenoic Acids
MH  - Leukotriene B4
MH  - Lipoxygenase/metabolism
MH  - Neutrophils/*physiopathology
MH  - Spondylitis, Ankylosing/*blood
MH  - Synovial Fluid/analysis
PMC - PMC371556
EDAT- 1980/11/01 00:00
MHDA- 1980/11/01 00:01
PMCR- 1980/11/01
CRDT- 1980/11/01 00:00
PHST- 1980/11/01 00:00 [pubmed]
PHST- 1980/11/01 00:01 [medline]
PHST- 1980/11/01 00:00 [entrez]
PHST- 1980/11/01 00:00 [pmc-release]
AID - 10.1172/JCI109947 [doi]
PST - ppublish
SO  - J Clin Invest. 1980 Nov;66(5):1166-70. doi: 10.1172/JCI109947.