PMID- 6260695
OWN - NLM
STAT- MEDLINE
DCOM- 19810613
LR  - 20190708
IS  - 0020-7136 (Print)
IS  - 0020-7136 (Linking)
VI  - 26
IP  - 6
DP  - 1980 Dec 15
TI  - Association of hepatitis B virus infection with hepatocellular carcinoma in 
      American patients.
PG  - 711-5
AB  - Thirty-four patients from the Philadelphia area with hepatocellular carcinoma 
      (HCC) were matched with colon cancer patients, lung cancer patients and blood 
      donors according to age and sex. Sera from the four groups were tested to 
      determine the prevalence of hepatitis B surface antigen (HBsAg), antibody to 
      HBsAg (anti-HBs), and antibody to hepatitis B core antigen (anti-HBc). Five of 
      the HCC patients (14.7%) and none of the controls were positive for HBsAg. At 
      least one of the three serologic markers of hepatitis B virus (HBV) infection was 
      found in 51.5% of the HCC patients, 5.3% of the colon cancer patients, 11.1% of 
      the lung cancer patients, and 10.7% of the blood donors. Twelve of the seventeen 
      seropositive HCC patients (70.6%) were positive for anti-HBc alone, while all of 
      the seropositive lung cancer patients and donors were positive for anti-HBs 
      alone. Sera positive for any HBV marker were also tested for e antigen (HBeAg) 
      and its antibody (anti-HBe). Four of the HCC patients (23.5% of the 
      seropositives) had anti-HBe, while none of the sera tested had HBeAg. A history 
      of alcoholism did not appear to influence HBV seropositivity in the HCC patients. 
      This study supports the hypothesis that HBV infection is closely associated with 
      HCC even in areas where both conditions are uncommon. The wide disparity between 
      seropositivity for HBsAg and anti-HBc in the HCC patients is an unusual feature, 
      for which an age effect may be the best explanation.
FAU - Yarrish, R L
AU  - Yarrish RL
FAU - Werner, B G
AU  - Werner BG
FAU - Blumberg, B S
AU  - Blumberg BS
LA  - eng
GR  - CA-0655/CA/NCI NIH HHS/United States
GR  - CA-06927/CA/NCI NIH HHS/United States
GR  - RR-05539/RR/NCRR NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Int J Cancer
JT  - International journal of cancer
JID - 0042124
RN  - 0 (Hepatitis B Antibodies)
RN  - 0 (Hepatitis B Surface Antigens)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alcoholism
MH  - Carcinoma, Hepatocellular/*etiology/immunology
MH  - Female
MH  - Hepatitis B/*complications/immunology
MH  - Hepatitis B Antibodies/analysis
MH  - Hepatitis B Surface Antigens/analysis
MH  - Humans
MH  - Liver Neoplasms/*etiology/immunology
MH  - Male
MH  - Middle Aged
MH  - Pennsylvania
EDAT- 1980/12/15 00:00
MHDA- 1980/12/15 00:01
CRDT- 1980/12/15 00:00
PHST- 1980/12/15 00:00 [pubmed]
PHST- 1980/12/15 00:01 [medline]
PHST- 1980/12/15 00:00 [entrez]
AID - 10.1002/ijc.2910260603 [doi]
PST - ppublish
SO  - Int J Cancer. 1980 Dec 15;26(6):711-5. doi: 10.1002/ijc.2910260603.