PMID- 6265112
OWN - NLM
STAT- MEDLINE
DCOM- 19810915
LR  - 20071114
IS  - 0190-1206 (Print)
IS  - 0190-1206 (Linking)
VI  - 4
IP  - 2
DP  - 1981
TI  - Retrospective validation of a new staging system for Wilms' tumor.
PG  - 167-71
AB  - Prognostic significance has been ascribed to certain clinicopathological features 
      of the Wilms' tumor. Examples are size, vascular invasion, histologic 
      characteristics, tumor rupture, and lymph nodal involvement. Several of these 
      were arranged into a grouping system, and used in a cooperative clinical trial, 
      the first National Wilms' Tumor Study (NWTS). Detailed clinicopathologic 
      information was accumulated for each patient entered in the study, and these data 
      were analyzed with respect to their prognostic import. Factors found to be of 
      significance were rearranged into a proposed staging system, believed more likely 
      to be predictive of outcome for patients with tumor spread beyond the kidney 
      confines, but without distant metastases (Groups II and III). The postulated 
      discriminatory superiority was tested using Group II and III patients entered in 
      the second NWTS. The same children were reassigned retrospectively to Stages II 
      and III, and the outcomes compared. Statistically significant differences were 
      noted between Stages II and III, but not for Groups II and III. These results 
      encourage the use of the new staging system in the third NWTS.
FAU - Farewell, V T
AU  - Farewell VT
FAU - D'Angio, G J
AU  - D'Angio GJ
FAU - Breslow, N
AU  - Breslow N
FAU - Norkool, P
AU  - Norkool P
LA  - eng
GR  - CA-11722/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Cancer Clin Trials
JT  - Cancer clinical trials
JID - 7905482
SB  - IM
MH  - Humans
MH  - Kidney Neoplasms/mortality/*pathology
MH  - Neoplasm Recurrence, Local
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Wilms Tumor/mortality/*pathology
EDAT- 1981/01/01 00:00
MHDA- 1981/01/01 00:01
CRDT- 1981/01/01 00:00
PHST- 1981/01/01 00:00 [pubmed]
PHST- 1981/01/01 00:01 [medline]
PHST- 1981/01/01 00:00 [entrez]
PST - ppublish
SO  - Cancer Clin Trials. 1981;4(2):167-71.