PMID- 6266652
OWN - NLM
STAT- MEDLINE
DCOM- 19811014
LR  - 20190720
IS  - 0304-3835 (Print)
IS  - 0304-3835 (Linking)
VI  - 12
IP  - 3
DP  - 1981 Apr
TI  - Mammary tumorigenicities of three chemically induced mouse kidney cell lines in 
      syngeneic female hosts.
PG  - 231-8
AB  - Three chemically induced, mammary tumour virus (MMTV) and leukemia virus (MuLV) 
      producing, baby mouse kidney (BMK) cell lines derived from respectively strains 
      BALB/c (-/HeA and -/CrglA) and C57BL/LiA were investigated for their mammary 
      tumour (MT) evoking potentials in syngeneic female hosts. An i.p. inoculated 
      virus-enriched fraction from A3 cells (BALB/c/HeA) had a similar oncogenic effect 
      as i.p. and s.c. inoculated whole A3 cells. The average MT ages were reduced in 
      all 3 groups. Cell lines BBM (BALB/c/CrglA) and BB (C57BL/LiA) were tested as 
      i.p. inoculated whole cells. Again, the average MT age was reduced in thus 
      treated BALB/c/Crgl females. In the case of C57BL/LiA the percentage of animals 
      with MT was strongly increased in the BB cell inoculated group (1 MT in control 
      group). Bioassay results corrected for intercurrent death cases (including 
      leukosis) were statistically significant. It is concluded that the endogenous 
      MMTV variants of the 3 mouse (sub-)strains are virulent MT evoking viruses in 
      autologous hosts when they are induced.
FAU - Links, J
AU  - Links J
FAU - Tol, O
AU  - Tol O
FAU - van der Valk, M A
AU  - van der Valk MA
FAU - Hart, G
AU  - Hart G
FAU - Timmermans, A
AU  - Timmermans A
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - Cancer Lett
JT  - Cancer letters
JID - 7600053
SB  - IM
MH  - Animals
MH  - *Cell Line
MH  - Female
MH  - Kidney
MH  - Leukemia Virus, Murine
MH  - Mammary Neoplasms, Experimental/chemically induced/*etiology
MH  - Mammary Tumor Virus, Mouse
MH  - Mice
MH  - Neoplasm Transplantation
MH  - Virulence
EDAT- 1981/04/01 00:00
MHDA- 1981/04/01 00:01
CRDT- 1981/04/01 00:00
PHST- 1981/04/01 00:00 [pubmed]
PHST- 1981/04/01 00:01 [medline]
PHST- 1981/04/01 00:00 [entrez]
AID - 0304-3835(81)90073-2 [pii]
AID - 10.1016/0304-3835(81)90073-2 [doi]
PST - ppublish
SO  - Cancer Lett. 1981 Apr;12(3):231-8. doi: 10.1016/0304-3835(81)90073-2.