PMID- 6268828
OWN - NLM
STAT- MEDLINE
DCOM- 19811118
LR  - 20200724
IS  - 0022-538X (Print)
IS  - 1098-5514 (Electronic)
IS  - 0022-538X (Linking)
VI  - 39
IP  - 2
DP  - 1981 Aug
TI  - Mammary tumor virus proviral DNA in normal murine tissue and non-virally induced 
      mammary tumors.
PG  - 367-76
AB  - The Southern DNA filter transfer technique was used to study the involvement of 
      the endogenous mouse mammary tumor virus (MMTV) in the development of mammary 
      tumors of nonviral etiology. The presence of extra MMTV proviruses in the genomes 
      of these non-virally induced mammary tumors would indicate an integration of the 
      provirus of an activated endogenous MMTV. Acquisition of MMTV proviruses did not 
      seem to be an absolute requirement for the development of hormone or 
      carcinogenically induced mammary tumors in strain BALB/c nor for hormone-induced 
      mammary tumors in mouse strains 020, C57BL, and C3Hf. In some hormone-induced 
      mammary tumors we did observe extra MMTV proviruses in submolar quantities, 
      indicating that reintegration may occasionally occur and that only a part of the 
      tumor cells acquired new MMTV DNA information. Hormone-dependent and -independent 
      primary mammary tumors of the mouse strain GR, which are controlled by the Mtv-2 
      mammary tumor induction gene, all acquired extra MMTV proviruses. Most of these 
      extra MMTV proviral-DNA-containing fragments appeared present in submolar 
      quantities, suggesting that only part of the tumor cells acquired extra MMTV 
      proviral information. These findings indicate that the initially transformed 
      mammary gland cells of non-virally induced mammary tumors do not necessarily 
      acquire extra MMTV proviral DNA information, in contrast to the MMTV-induced 
      mammary tumors, in which all tumor cells contain extra MMTV DNA information.
FAU - Michalides, R
AU  - Michalides R
FAU - Wagenaar, E
AU  - Wagenaar E
FAU - Groner, B
AU  - Groner B
FAU - Hynes, N E
AU  - Hynes NE
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Virol
JT  - Journal of virology
JID - 0113724
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Animals
MH  - DNA, Viral/*analysis
MH  - Female
MH  - *Genes, Viral
MH  - Liver/*analysis
MH  - Mammary Neoplasms, Experimental/*analysis/etiology
MH  - Mammary Tumor Virus, Mouse/*genetics
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C3H
MH  - Mice, Inbred C57BL
MH  - Mice, Inbred Strains
MH  - Recombination, Genetic
PMC - PMC171345
EDAT- 1981/08/01 00:00
MHDA- 1981/08/01 00:01
PMCR- 1981/08/01
CRDT- 1981/08/01 00:00
PHST- 1981/08/01 00:00 [pubmed]
PHST- 1981/08/01 00:01 [medline]
PHST- 1981/08/01 00:00 [entrez]
PHST- 1981/08/01 00:00 [pmc-release]
AID - 10.1128/JVI.39.2.367-376.1981 [doi]
PST - ppublish
SO  - J Virol. 1981 Aug;39(2):367-76. doi: 10.1128/JVI.39.2.367-376.1981.