PMID- 6274669 OWN - NLM STAT- MEDLINE DCOM- 19820322 LR - 20190624 IS - 0014-2999 (Print) IS - 0014-2999 (Linking) VI - 75 IP - 4 DP - 1981 Nov 5 TI - Suppressive action of cholecystokinin octapeptide on the behavioral effects of L-DOPA in the rat. PG - 313-6 AB - Intracerebroventricular (i.c.v.) administration of cholecystokinin octapeptide (CCK-8) appeared to suppress the effects of L-DOPA and antagonize the actions of thyrotropin-releasing hormone (TRH). This was not only proved by the behavioral rating, but also by locomotor activity counting. thus, the sedative action of CCK-8 and the antagonizing effect of this peptide on the central actions of TRH were clearly demonstrated. FAU - Itoh, S AU - Itoh S FAU - Katsuura, G AU - Katsuura G LA - eng PT - Journal Article PL - Netherlands TA - Eur J Pharmacol JT - European journal of pharmacology JID - 1254354 RN - 0 (Peptide Fragments) RN - 46627O600J (Levodopa) RN - 5Y5F15120W (Thyrotropin-Releasing Hormone) RN - 9011-97-6 (Cholecystokinin) RN - 9MV14S8G3E (Pargyline) RN - M03GIQ7Z6P (Sincalide) SB - IM MH - Animals MH - Behavior, Animal/*drug effects MH - Cholecystokinin/*pharmacology MH - Levodopa/*pharmacology MH - Male MH - Motor Activity/drug effects MH - Pargyline/pharmacology MH - Peptide Fragments/*pharmacology MH - Rats MH - Rats, Inbred Strains MH - Sincalide MH - Thyrotropin-Releasing Hormone/*antagonists & inhibitors EDAT- 1981/11/05 00:00 MHDA- 1981/11/05 00:01 CRDT- 1981/11/05 00:00 PHST- 1981/11/05 00:00 [pubmed] PHST- 1981/11/05 00:01 [medline] PHST- 1981/11/05 00:00 [entrez] AID - 0014-2999(81)90559-8 [pii] AID - 10.1016/0014-2999(81)90559-8 [doi] PST - ppublish SO - Eur J Pharmacol. 1981 Nov 5;75(4):313-6. doi: 10.1016/0014-2999(81)90559-8.