PMID- 6275867
OWN - NLM
STAT- MEDLINE
DCOM- 19820412
LR  - 20190825
IS  - 0166-4328 (Print)
IS  - 0166-4328 (Linking)
VI  - 4
IP  - 1
DP  - 1982 Jan
TI  - Intracerebroventricular administration of nanogram amounts of beta-endorphin and 
      Met-enkephalin causes retrograde amnesia in rats.
PG  - 111-5
AB  - The intracerebroventricular (icv) administration of 5.0 or 25.0 ng of 
      beta-endorphin or Met-enkephalin causes retrograde amnesia for a shuttle 
      avoidance task ion rats. In both cases, the higher dose was more effective than 
      the lower one. The present results confirm previous similar findings obtained 
      using systemic administrations of these compounds, and suggest that the amnestic 
      effect of beta-endorphin and Met-enkephalin is mediated centrally.
FAU - Lucion, A B
AU  - Lucion AB
FAU - Rosito, G
AU  - Rosito G
FAU - Sapper, D
AU  - Sapper D
FAU - Palmini, A L
AU  - Palmini AL
FAU - Izquierdo, I
AU  - Izquierdo I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Endorphins)
RN  - 0 (Enkephalins)
RN  - 58569-55-4 (Enkephalin, Methionine)
RN  - 60617-12-1 (beta-Endorphin)
SB  - IM
MH  - Amnesia/*chemically induced
MH  - Amnesia, Retrograde/*chemically induced
MH  - Animals
MH  - Avoidance Learning
MH  - Dose-Response Relationship, Drug
MH  - Endorphins/*administration & dosage
MH  - Enkephalin, Methionine
MH  - Enkephalins/*administration & dosage
MH  - Female
MH  - Humans
MH  - Injections, Intraventricular
MH  - Rats
MH  - Rats, Inbred Strains
MH  - beta-Endorphin
EDAT- 1982/01/01 00:00
MHDA- 1982/01/01 00:01
CRDT- 1982/01/01 00:00
PHST- 1982/01/01 00:00 [pubmed]
PHST- 1982/01/01 00:01 [medline]
PHST- 1982/01/01 00:00 [entrez]
AID - 0166-4328(82)90169-3 [pii]
AID - 10.1016/0166-4328(82)90169-3 [doi]
PST - ppublish
SO  - Behav Brain Res. 1982 Jan;4(1):111-5. doi: 10.1016/0166-4328(82)90169-3.