PMID- 6277477
OWN - NLM
STAT- MEDLINE
DCOM- 19820512
LR  - 20091119
IS  - 0008-5472 (Print)
IS  - 0008-5472 (Linking)
VI  - 42
IP  - 3
DP  - 1982 Mar
TI  - Mammary tumor virus DNA as a marker for genotypic variance within 
      hormone-responsive GR mouse mammary tumors.
PG  - 1154-8
AB  - Mammary tumors of GR mice acquire extra mammary tumor virus (MMTV) DNA 
      information within their DNA during tumor growth and development. These extra 
      MMTV genes have been used by us as genotypic markers to investigate the 
      heterogeneity of GR mammary tumors and their loss of hormone dependence during 
      serial transplantation. Our studies reveal that the various subpopulations of 
      cells within individual GR mammary tumors are characterized by differences in 
      number and location of acquired extra MMTV DNA fragments. Losses of certain of 
      these extra MMTV DNA fragments occur when mammary tumors become hormone 
      independent, indicating a loss of hormone-dependent cells. The study of MMTV DNA 
      markers also reveals that low levels of autonomous cells are already present in 
      some hormone-dependent mammary tumors at an early stage of their development. The 
      genotypic analysis strongly indicates that mammary tumor progression is not due 
      to phenotypic adaptation but to clonal selection of the more aggressive sublines.
FAU - Michalides, R
AU  - Michalides R
FAU - Wagenaar, E
AU  - Wagenaar E
FAU - Sluyser, M
AU  - Sluyser M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cancer Res
JT  - Cancer research
JID - 2984705R
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Animals
MH  - DNA, Viral/*metabolism
MH  - Gammaretrovirus/ultrastructure
MH  - Genes, Viral
MH  - *Genotype
MH  - Mammary Neoplasms, Experimental/*metabolism/pathology/ultrastructure
MH  - Mice
MH  - Neoplasm Transplantation
MH  - Neoplasms, Hormone-Dependent
MH  - Phenotype
MH  - Selection, Genetic
MH  - Tumor Virus Infections/ultrastructure
EDAT- 1982/03/01 00:00
MHDA- 1982/03/01 00:01
CRDT- 1982/03/01 00:00
PHST- 1982/03/01 00:00 [pubmed]
PHST- 1982/03/01 00:01 [medline]
PHST- 1982/03/01 00:00 [entrez]
PST - ppublish
SO  - Cancer Res. 1982 Mar;42(3):1154-8.