PMID- 6277498
OWN - NLM
STAT- MEDLINE
DCOM- 19820512
LR  - 20190705
IS  - 0092-8674 (Print)
IS  - 0092-8674 (Linking)
VI  - 27
IP  - 2 Pt 1
DP  - 1981 Dec
TI  - Glucocorticoid regulation of the Ha-MuSV p21 gene conferred by sequences from 
      mouse mammary tumor virus.
PG  - 245-55
AB  - Molecular chimeras with the p21 transforming gene of Harvey murine sarcoma virus 
      linked to DNA containing the long terminal repeat (LTR) or mouse mammary tumor 
      virus (MMTV) have been constructed. Transformants of NIH 3T3 cells induced by 
      transfection with MMTV LTR-p21 hybrid DNA have been identified that express the 
      normal p21 gene product. The levels of p21 RNA and protein in these transformants 
      are regulated by physiological concentrations of dexamethasone, a synthetic 
      glucocorticoid hormone. Hybrid transcripts containing p21 gene sequences 
      originate at the normal MMTV viral initiation site. It is concluded that 
      sequences necessary for hormonal control of transcription are completely 
      specified by the viral genome and probably map within the viral LTR.
FAU - Huang, A L
AU  - Huang AL
FAU - Ostrowski, M C
AU  - Ostrowski MC
FAU - Berard, D
AU  - Berard D
FAU - Hager, G L
AU  - Hager GL
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
RN  - 0 (DNA, Recombinant)
RN  - 0 (DNA, Viral)
RN  - 0 (Glucocorticoids)
RN  - 0 (Viral Proteins)
RN  - 7S5I7G3JQL (Dexamethasone)
RN  - EC 3.1.21.- (DNA Restriction Enzymes)
RN  - EC 3.6.5.2 (Oncogene Protein p21(ras))
SB  - IM
MH  - Animals
MH  - Cloning, Molecular/methods
MH  - DNA Restriction Enzymes
MH  - DNA, Recombinant
MH  - *DNA, Viral
MH  - Dexamethasone/pharmacology
MH  - Gene Expression Regulation/*drug effects
MH  - Glucocorticoids/*pharmacology
MH  - Mammary Tumor Virus, Mouse/*genetics
MH  - Mice
MH  - Oncogene Protein p21(ras)
MH  - Phenotype
MH  - Sarcoma Viruses, Murine/genetics
MH  - Transfection
MH  - Viral Proteins/*genetics
EDAT- 1981/12/01 00:00
MHDA- 1981/12/01 00:01
CRDT- 1981/12/01 00:00
PHST- 1981/12/01 00:00 [pubmed]
PHST- 1981/12/01 00:01 [medline]
PHST- 1981/12/01 00:00 [entrez]
AID - 0092-8674(81)90408-6 [pii]
AID - 10.1016/0092-8674(81)90408-6 [doi]
PST - ppublish
SO  - Cell. 1981 Dec;27(2 Pt 1):245-55. doi: 10.1016/0092-8674(81)90408-6.