PMID- 6279827
OWN - NLM
STAT- MEDLINE
DCOM- 19820621
LR  - 20190511
IS  - 0022-3751 (Print)
IS  - 1469-7793 (Electronic)
IS  - 0022-3751 (Linking)
VI  - 321
DP  - 1981 Dec
TI  - Post-tetanic potentiation and facilitation of synaptic potentials evoked in cat 
      spinal motoneurones.
PG  - 97-109
AB  - 1. Excitatory post-synaptic potentials (e.p.s.p.s) were evoked in spinal 
      alpha-motoneurones of the cat by impulses in single group Ia nerve fibres. 2. The 
      average peak amplitude of some of these e.p.s.p.s was increased by a conditioning 
      tetanus. The maximum increase observed was 54% of the control amplitude. 3. The 
      average peak amplitude of some e.p.s.p.s was increased by a single conditioning 
      stimulus which preceded the test stimulus by 1 or 2 msec. The maximum increase 
      observed was 28% of the control amplitude. 4. The ability of e.p.s.p.s to 
      potentiate following a tetanus was correlated with their ability to be 
      facilitated by a single conditioning stimulus. 5. If an e.p.s.p. could be 
      facilitated prior to a tetanus, the amount of facilitation was reduced after the 
      tetanus, with all facilitation being abolished when post-tetanic potentiation was 
      maximal. 6. The fluctuations of an e.p.s.p. were analysed before and after a 
      tetanus. The peak amplitudes that an e.p.s.p. fluctuated between while 
      potentiated did not gradually diminish as the effect of the tetanus disappeared. 
      Post-tetanic potentiation, when it occurred, was accompanied by a decrease in the 
      probability of occurrence of components with smaller peak amplitudes and an 
      increase in the probability of occurrence of components with larger peak 
      amplitudes. 7. These results are consistent with the suggestion that the 
      magnitude of the synaptic potential generated at a single bouton does not vary 
      from trial to trial (Jack, Redman & Wong, 1981a). Nor does the amplitude of this 
      potential vary following a single conditioning stimulus or a tetanus. 
      Post-tetanic potentiation and facilitation result from a decrease in the 
      probability of failure to release transmitter following the conditioning stimuli.
FAU - Hirst, G D
AU  - Hirst GD
FAU - Redman, S J
AU  - Redman SJ
FAU - Wong, K
AU  - Wong K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Physiol
JT  - The Journal of physiology
JID - 0266262
SB  - IM
MH  - Animals
MH  - Cats
MH  - Evoked Potentials
MH  - Motor Neurons/*physiology
MH  - Muscle Contraction
MH  - Neurons, Afferent/physiology
MH  - Spinal Cord/*physiology
MH  - Synapses/*physiology
MH  - Synaptic Transmission
PMC - PMC1249615
EDAT- 1981/12/01 00:00
MHDA- 1981/12/01 00:01
PMCR- 1981/12/01
CRDT- 1981/12/01 00:00
PHST- 1981/12/01 00:00 [pubmed]
PHST- 1981/12/01 00:01 [medline]
PHST- 1981/12/01 00:00 [entrez]
PHST- 1981/12/01 00:00 [pmc-release]
AID - 10.1113/jphysiol.1981.sp013973 [doi]
PST - ppublish
SO  - J Physiol. 1981 Dec;321:97-109. doi: 10.1113/jphysiol.1981.sp013973.