PMID- 6280844
OWN - NLM
STAT- MEDLINE
DCOM- 19820722
LR  - 20190620
IS  - 0008-543X (Print)
IS  - 0008-543X (Linking)
VI  - 49
IP  - 12
DP  - 1982 Jun 15
TI  - Alpha-1-antitrypsin deficiency in Southern African hepatocellular carcinoma 
      patients. An immunoperoxidase and histochemical study.
PG  - 2537-40
AB  - An increased frequency of alpha-1-antitrypsin deficiency (AATD) has been reported 
      in patients with hepatocellular carcinoma (HCC) in Scandinavia and England. Using 
      a specific immunoperoxidase technique for alpha-1-antitrypsin (AAT) and periodic 
      acid-Schiff (PAS) with and without diastase predigestion, the authors examined 
      nonneoplastic autopsy liver tissue from 58 black southern African patients with 
      HCC and from 54 controls. No periportal PAS-positive diastase-resistant globules 
      containing AAT (specific for AATD) were found in liver tissue from either group. 
      A finely granular diffuse cytoplasmic AAT staining (not removed by diastase 
      predigestion) was present in hepatocytes in a "checkerboard" pattern within the 
      lobule in 33 (57%) HCC patients and in 20 (37%) controls (P greater than 0.1), 
      and was particularly prominent adjacent to tumor in 11 HCC patients. 
      Alpha-1-antitrypsin was present in neoplastic cells in 18 of the 40 HCC examined 
      (45%). These findings suggest no major role for AATD in the etiology of HCC in 
      southern Africa.
FAU - Cohen, C
AU  - Cohen C
FAU - Berson, S D
AU  - Berson SD
FAU - Budgeon, L R
AU  - Budgeon LR
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cancer
JT  - Cancer
JID - 0374236
SB  - IM
MH  - Carcinoma, Hepatocellular/*blood
MH  - Histocytochemistry
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Liver Neoplasms/*blood
MH  - Periodic Acid-Schiff Reaction
MH  - Phenotype
MH  - *alpha 1-Antitrypsin Deficiency
EDAT- 1982/06/15 00:00
MHDA- 1982/06/15 00:01
CRDT- 1982/06/15 00:00
PHST- 1982/06/15 00:00 [pubmed]
PHST- 1982/06/15 00:01 [medline]
PHST- 1982/06/15 00:00 [entrez]
AID - 10.1002/1097-0142(19820615)49:12<2537::aid-cncr2820491222>3.0.co;2-7 [doi]
PST - ppublish
SO  - Cancer. 1982 Jun 15;49(12):2537-40. doi: 
      10.1002/1097-0142(19820615)49:12<2537::aid-cncr2820491222>3.0.co;2-7.