PMID- 6281507
OWN - NLM
STAT- MEDLINE
DCOM- 19820719
LR  - 20190829
IS  - 0021-521X (Print)
IS  - 0021-521X (Linking)
VI  - 32
IP  - 1
DP  - 1982
TI  - Sedative action of cholecystokinin octapeptide on behavioral excitation by 
      thyrotropin releasing hormone and methamphetamine in the rat.
PG  - 83-91
AB  - Intracerebroventricular (i.c.v.) injection of C-terminal octapeptide of 
      cholecystokinin (CCK-8) in rats prolonged pentobarbital- and ethanol-induced 
      sleeping time, but non-sulfated CCD-8 (CCK-8-NS) had no effect and caerulein 
      showed a tendency to prolong the pentobarbital narcosis. On the other hand, 
      i.c.v. injection of thyrotropin releasing hormone (TRH) shortened the sleeping 
      time and the effect of CCK-8 was apparently antagonized by combined 
      administration of TRH. Spontaneous locomotor activity in the late morning and 
      early afternoon was not affected by CCK-8, but it increased following i.c.v. 
      injection of CCK-8-NS. Hyperactivity produced by TRH and methamphetamine was 
      suppressed by i.c.v. injection of CCK-8, while CCK-8-NS showed a tendency to 
      enhance the methamphetamine-induced hyperactivity and caerulein had no effect. 
      These results indicate that CCK-8 has a sedative action and antagonizes the 
      behavioral excitation caused by TRH and methamphetamine, but that the effects of 
      CCK-8-NS and caerulein were rather the opposite of those of CCK-8. In an 
      additional experiment the TRH-induced body shaking response was not affected by 
      combined administration of CCK-8.
FAU - Katsuura, G
AU  - Katsuura G
FAU - Itoh, S
AU  - Itoh S
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Jpn J Physiol
JT  - The Japanese journal of physiology
JID - 2985184R
RN  - 0 (Hypnotics and Sedatives)
RN  - 0 (Peptide Fragments)
RN  - 3K9958V90M (Ethanol)
RN  - 44RAL3456C (Methamphetamine)
RN  - 5Y5F15120W (Thyrotropin-Releasing Hormone)
RN  - 888Y08971B (Ceruletide)
RN  - 9011-97-6 (Cholecystokinin)
RN  - I4744080IR (Pentobarbital)
RN  - M03GIQ7Z6P (Sincalide)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/*drug effects
MH  - Brain/drug effects
MH  - Ceruletide/pharmacology
MH  - Cholecystokinin/administration & dosage/*pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Ethanol/pharmacology
MH  - Hypnotics and Sedatives/*pharmacology
MH  - Male
MH  - Methamphetamine/*antagonists & inhibitors/pharmacology
MH  - Motor Activity/drug effects
MH  - Pentobarbital/pharmacology
MH  - Peptide Fragments/administration & dosage/*pharmacology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Sincalide
MH  - Sleep/drug effects
MH  - Thyrotropin-Releasing Hormone/administration & dosage/*antagonists & 
      inhibitors/pharmacology
EDAT- 1982/01/01 00:00
MHDA- 1982/01/01 00:01
CRDT- 1982/01/01 00:00
PHST- 1982/01/01 00:00 [pubmed]
PHST- 1982/01/01 00:01 [medline]
PHST- 1982/01/01 00:00 [entrez]
AID - 10.2170/jjphysiol.32.83 [doi]
PST - ppublish
SO  - Jpn J Physiol. 1982;32(1):83-91. doi: 10.2170/jjphysiol.32.83.