PMID- 628217
OWN - NLM
STAT- MEDLINE
DCOM- 19780426
LR  - 20190819
IS  - 0022-4790 (Print)
IS  - 0022-4790 (Linking)
VI  - 10
IP  - 1
DP  - 1978
TI  - Chemotherapy in recurrent noncystic low-grade astrocytomas of the cerebrum in 
      children.
PG  - 45-54
AB  - Six children with grade II astrocytomas were treated with combination 
      chemotherapy consisting of 1,3 bis(2-chloroethyl) 1-nitrosourea (BCNU). 
      Vincristine (VCR), intrathecal Methotrexate (i.t. MTX), and Dexamethasone. Of the 
      children, 3 showed a partial remission, and 1 other showed clinical improvement. 
      Our data suggest that chemotherapy is effective in low-grade astrocytomas, and 
      there is now a need for larger trials in low-grade astrocytomas to document the 
      role of chemotherapy accurately in these tumors. It is suggested that trials of 
      chemotherapy as adjuvant to surgery and radiotherapy should be initiated.
FAU - Sumer, T
AU  - Sumer T
FAU - Freeman, A I
AU  - Freeman AI
FAU - Cohen, M
AU  - Cohen M
FAU - Bremer, A M
AU  - Bremer AM
FAU - Thomas, P R
AU  - Thomas PR
FAU - Sinks, L F
AU  - Sinks LF
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Surg Oncol
JT  - Journal of surgical oncology
JID - 0222643
RN  - 0 (Antineoplastic Agents)
RN  - 5J49Q6B70F (Vincristine)
RN  - 7S5I7G3JQL (Dexamethasone)
RN  - U68WG3173Y (Carmustine)
RN  - YL5FZ2Y5U1 (Methotrexate)
SB  - IM
MH  - Antineoplastic Agents/*therapeutic use
MH  - Astrocytoma/*drug therapy
MH  - Brain Neoplasms/*drug therapy
MH  - Carmustine/therapeutic use
MH  - Child
MH  - Child, Preschool
MH  - Dexamethasone/therapeutic use
MH  - Drug Therapy, Combination
MH  - Female
MH  - Humans
MH  - Infant
MH  - Male
MH  - Methotrexate/therapeutic use
MH  - Neoplasm Recurrence, Local/*drug therapy
MH  - Remission, Spontaneous
MH  - Vincristine/therapeutic use
EDAT- 1978/01/01 00:00
MHDA- 1978/01/01 00:01
CRDT- 1978/01/01 00:00
PHST- 1978/01/01 00:00 [pubmed]
PHST- 1978/01/01 00:01 [medline]
PHST- 1978/01/01 00:00 [entrez]
AID - 10.1002/jso.2930100108 [doi]
PST - ppublish
SO  - J Surg Oncol. 1978;10(1):45-54. doi: 10.1002/jso.2930100108.