PMID- 6294390
OWN - NLM
STAT- MEDLINE
DCOM- 19830225
LR  - 20190829
IS  - 0021-521X (Print)
IS  - 0021-521X (Linking)
VI  - 32
IP  - 4
DP  - 1982
TI  - Effect of cholecystokinin octapeptide and vasoactive intestinal polypeptide on 
      adrenocortical secretion in the rat.
PG  - 553-60
AB  - Intraperitoneal (i.p.) injection of C-terminal octapeptide of cholecystokinin 
      (CCK-8) produced a dose-related increase in plasma corticosterone levels in 
      intact rats, but not in vagotomized ones. Intracerebroventricular (i.c.v.) 
      injection of CCK-8 was ineffective in stimulating the secretion of 
      corticosterone, and in vitro experiment on ACTH release indicated that CCK-8 
      could not affect pituitary tissue directly. Since i.p. injection of non-sulfated 
      CCK-8 failed to elevate plasma corticosterone levels, sulfated tyrosine residue 
      in the CCK molecule is assumed to be indispensable for the stimulation of 
      visceral organs. On the other hand, vasoactive intestinal polypeptide (VIP) was 
      found to cause a dose-dependent increase in plasma corticosterone levels when 
      administered centrally, but not after i.p. injection. However, VIP could not 
      stimulate the release of ACTH from the pituitary tissue directly. The results 
      suggest that VIP, but not CCK, stimulates the hypothalamic CRF neurons either 
      directly or indirectly.
FAU - Itoh, S
AU  - Itoh S
FAU - Hirota, R
AU  - Hirota R
FAU - Katsuura, G
AU  - Katsuura G
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Jpn J Physiol
JT  - The Japanese journal of physiology
JID - 2985184R
RN  - 0 (Gastrointestinal Hormones)
RN  - 0 (Peptide Fragments)
RN  - 37221-79-7 (Vasoactive Intestinal Peptide)
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
RN  - 9011-97-6 (Cholecystokinin)
RN  - M03GIQ7Z6P (Sincalide)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Adrenal Cortex/*drug effects
MH  - Adrenocorticotropic Hormone/metabolism
MH  - Animals
MH  - Cholecystokinin/*pharmacology
MH  - Corticosterone/metabolism
MH  - Dose-Response Relationship, Drug
MH  - Gastrointestinal Hormones/*pharmacology
MH  - In Vitro Techniques
MH  - Male
MH  - Peptide Fragments/*pharmacology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Sincalide
MH  - Vagotomy
MH  - Vasoactive Intestinal Peptide/*pharmacology
EDAT- 1982/01/01 00:00
MHDA- 1982/01/01 00:01
CRDT- 1982/01/01 00:00
PHST- 1982/01/01 00:00 [pubmed]
PHST- 1982/01/01 00:01 [medline]
PHST- 1982/01/01 00:00 [entrez]
AID - 10.2170/jjphysiol.32.553 [doi]
PST - ppublish
SO  - Jpn J Physiol. 1982;32(4):553-60. doi: 10.2170/jjphysiol.32.553.