PMID- 6301594
OWN - NLM
STAT- MEDLINE
DCOM- 19830610
LR  - 20190511
IS  - 0007-1188 (Print)
IS  - 0007-1188 (Linking)
VI  - 68
IP  - 3
DP  - 1980 Mar
TI  - The role of cyclic nucleotides and related compounds in nerve-mediated 
      vasodilatation in the cat submandibular gland.
PG  - 485-97
AB  - 1 Intra-arterial administration of a number of purine compounds to the cat 
      submandibular salivary gland led to an increased blood flow. The threshold 
      concentration of the most potent vasodilators, adenosine 5'-triphosphate (ATP) 
      and adenosine 5'-diphosphate (ADP) was about 2 mumol/l. Adenosine and guanosine 
      5'-triphosphate (GTP) required about 25 mumol/l, adenosine 3',5'-cyclic 
      monophosphate (cyclic AMP) 40 mumol/l, guanosine 5'-diphosphate (GDP) 125 mumol/l 
      and dibutyryl guanosine 3',5' cyclic monophosphate (db cyclic GMP) 400 mumol/l. 
      Dibutyryl cyclic AMP and cyclic GMP were ineffective. 2 The cyclic nucleotide 
      phosphodiesterase inhibitors, theophylline, papaverine, quinine and 
      3-isobutyl-1-methylxanthine (IBMX), all acted as vasodilators. 3 When 
      intra-arterial infusion of theophylline or IBMX was combined with sympathetic 
      nerve stimulation, the vasodilatation observed after the stimulus ceased was 
      significantly potentiated. 4 Theophylline and IBMX also potentiated the 
      vasodilatation accompanying parasympathetic nerve stimulation and this response 
      persisted after atropine. 5 These results are discussed in relation to the 
      possible mediators of sympathetic and parasympathetic vasodilatation in the 
      gland.
FAU - Jones, C J
AU  - Jones CJ
FAU - Mann, G E
AU  - Mann GE
FAU - Smaje, L H
AU  - Smaje LH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Br J Pharmacol
JT  - British journal of pharmacology
JID - 7502536
RN  - 0 (Nucleotides, Cyclic)
RN  - 0 (Phosphodiesterase Inhibitors)
RN  - 0 (Purines)
RN  - 0 (Receptors, Adrenergic, beta)
RN  - 64ALC7F90C (Dipyridamole)
RN  - 7C0697DR9I (Atropine)
RN  - C137DTR5RG (Theophylline)
RN  - EC 3.4.21.- (Kallikreins)
SB  - IM
MH  - Animals
MH  - Atropine/pharmacology
MH  - Cats
MH  - Dipyridamole/pharmacology
MH  - Electric Stimulation
MH  - Female
MH  - Kallikreins/physiology
MH  - Male
MH  - Nucleotides, Cyclic/*physiology
MH  - Parasympathetic Nervous System/physiology
MH  - Phosphodiesterase Inhibitors/pharmacology
MH  - Purines/pharmacology
MH  - Receptors, Adrenergic, beta/physiology
MH  - Regional Blood Flow/drug effects
MH  - Submandibular Gland/*blood supply/innervation
MH  - Sympathetic Nervous System/*physiology
MH  - Theophylline/pharmacology
MH  - Vasodilation/*drug effects
PMC - PMC2044196
EDAT- 1980/03/01 00:00
MHDA- 1980/03/01 00:01
PMCR- 1981/03/01
CRDT- 1980/03/01 00:00
PHST- 1980/03/01 00:00 [pubmed]
PHST- 1980/03/01 00:01 [medline]
PHST- 1980/03/01 00:00 [entrez]
PHST- 1981/03/01 00:00 [pmc-release]
AID - 10.1111/j.1476-5381.1980.tb14563.x [doi]
PST - ppublish
SO  - Br J Pharmacol. 1980 Mar;68(3):485-97. doi: 10.1111/j.1476-5381.1980.tb14563.x.