PMID- 6301918
OWN - NLM
STAT- MEDLINE
DCOM- 19830610
LR  - 20141003
IS  - 0016-450X (Print)
IS  - 0016-450X (Linking)
VI  - 74
IP  - 1
DP  - 1983 Feb
TI  - Quantitative analysis of mouse mammary tumor virus in milk in two sublines of 
      RIII/AnOk mice with low and high mammary tumor incidence.
PG  - 69-76
AB  - Mammary tumors have ceased to develop in descendants of one female of the 
      RIII/AnOk mouse strain which was brought from the Mouse Colony of Okayama 
      University Medical School in 1975, while descendants of another female of this 
      strain have maintained a high tumor incidence. The former and latter descendants 
      were separated out as RIII/AnOk/2 and RIII/AnOk/1 sublines, respectively. The 
      amount of mouse mammary tumor virus (MMTV) in the milk of individual females in 
      these two sublines was determined by means of a sensitive enzyme immunoassay. No 
      MMTV antigens were detected in 59 milk samples of RIII/AnOk/2 females collected 
      during the 1st to 7th lactation periods. On the other hand, all the milk samples 
      of RIII/AnOk/1 females contained MMTV antigens with concentrations ranging from 9 
      to 400 micrograms/ml. When RIII/AnOk/2 mice were foster-nursed by RIII/AnOk/1 
      mothers, the infected RIII/AnOk/2 females produced MMTV in the milk to almost the 
      same degree as did the RIII/AnOk/1 females. No genetic differences between the 
      two sublines were observed by the use of reciprocal skin grafting, tumor 
      transplantation, and analysis of biochemical genetic markers. These results 
      indicate that the arrest of mammary tumor development in the RIII/AnOk/2 subline 
      was due to the disappearance of MMTV in the milk.
FAU - Takahashi, M
AU  - Takahashi M
FAU - Saga, S
AU  - Saga S
FAU - Nagayoshi, S
AU  - Nagayoshi S
FAU - Imai, M
AU  - Imai M
FAU - Tsutsui, Y
AU  - Tsutsui Y
FAU - Hoshino, M
AU  - Hoshino M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Gan
JT  - Gan
JID - 0151745
SB  - IM
MH  - Animals
MH  - Female
MH  - Immunoenzyme Techniques
MH  - Mammary Neoplasms, Experimental/*etiology
MH  - Mammary Tumor Virus, Mouse/*isolation & purification
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Milk/*microbiology
MH  - Pedigree
MH  - Retroviridae/*isolation & purification
MH  - Viral Interference
EDAT- 1983/02/01 00:00
MHDA- 1983/02/01 00:01
CRDT- 1983/02/01 00:00
PHST- 1983/02/01 00:00 [pubmed]
PHST- 1983/02/01 00:01 [medline]
PHST- 1983/02/01 00:00 [entrez]
PST - ppublish
SO  - Gan. 1983 Feb;74(1):69-76.