PMID- 6303198
OWN - NLM
STAT- MEDLINE
DCOM- 19830623
LR  - 20161031
IS  - 0003-4266 (Print)
IS  - 0003-4266 (Linking)
VI  - 43
IP  - 5
DP  - 1982 Oct-Nov
TI  - [Is the regulation of the expression of MMTV proviruses in various cell types 
      linked to glucocorticoid receptors and/or the structure of chromatin?].
PG  - 384-91
AB  - The expression of the mouse mammary tumor virus (MMTV) was studied in 
      undifferentiated embryonal carcinoma cells (EC), in partially differentiated 
      myoblasts derived from EC cells and in fully differentiated myotubes. Whereas no 
      MMTV RNA could be detected in EC cells, relatively large amounts of tumor virus 
      RNA were found in myoblasts. The MMTV RNA level was reduced in myotubes derived 
      from myoblastic differenciation. DNaseI sensibility of MMTV DNA in chromatin 
      allows us to show conformational changes in EC cell myoblasts and GR mammary cell 
      chromatin which could be associated with MMTV RNA synthesis. The glucocorticoid 
      hormones dexamethasone which stimulates the MMTV RNA synthesis in differentiated 
      mammary cells did not affect this synthesis in myoblasts. By contrast, the 
      reduced synthesis of MMTV RNA in myotubes was overcome with dexamethasone. The 
      differential MMTV RNA synthesis is not related to different amount of receptor 
      and its hormonal regulation is not associated with a conformational change of 
      chromatin.
FAU - Defer, N
AU  - Defer N
FAU - Gros, D
AU  - Gros D
FAU - Crepin, M
AU  - Crepin M
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - La regulation de l'expression des provirus MMTV dans differents types cellulaires 
      est-elle liee aux recepteurs des glucocorticoides et/ou a la structure de la 
      chromatine?
PL  - France
TA  - Ann Endocrinol (Paris)
JT  - Annales d'endocrinologie
JID - 0116744
RN  - 0 (Chromatin)
RN  - 0 (Receptors, Glucocorticoid)
RN  - 0 (Receptors, Steroid)
RN  - 7S5I7G3JQL (Dexamethasone)
SB  - IM
MH  - Animals
MH  - Cell Differentiation
MH  - Cell Line
MH  - Chromatin/*metabolism
MH  - Dexamethasone/pharmacology
MH  - *Gene Expression Regulation
MH  - Mammary Tumor Virus, Mouse/*genetics
MH  - Mice
MH  - Protein Conformation
MH  - Receptors, Glucocorticoid/*physiology
MH  - Receptors, Steroid/*physiology
EDAT- 1982/10/01 00:00
MHDA- 1982/10/01 00:01
CRDT- 1982/10/01 00:00
PHST- 1982/10/01 00:00 [pubmed]
PHST- 1982/10/01 00:01 [medline]
PHST- 1982/10/01 00:00 [entrez]
PST - ppublish
SO  - Ann Endocrinol (Paris). 1982 Oct-Nov;43(5):384-91.