PMID- 6305506
OWN - NLM
STAT- MEDLINE
DCOM- 19830826
LR  - 20190705
IS  - 0092-8674 (Print)
IS  - 0092-8674 (Linking)
VI  - 33
IP  - 2
DP  - 1983 Jun
TI  - Tumorigenesis by mouse mammary tumor virus: evidence for a common region for 
      provirus integration in mammary tumors.
PG  - 369-77
AB  - We have prepared specific probes for unique-sequence cellular DNA adjacent to 
      each of the newly integrated proviruses in tumors induced by mouse mammary tumor 
      virus (MMTV). The use of such probes to screen a large number of independent 
      mammary tumors in the BR6 strain of mouse has indicated that in at least 17 out 
      of the 40 tumors examined so far, an MMTV provirus has integrated into a common 
      chromosomal domain. A 10 kb Eco RI fragment of single copy DNA from this region 
      has been isolated and partially characterized by restriction enzyme mapping. Of 
      the proviruses located within this fragment in different tumors, all but one are 
      complete, in the same orientation, and clustered within about 3 kb of cellular 
      DNA. These findings are consistent with an insertional mutagenesis model for 
      tumorigenesis by MMTV, in which the integration of a provirus in a particular 
      region of cellular DNA may activate a neighboring oncogene. The region we 
      describe here appears to be different from that reported for mammary tumors in 
      the C3H strain of mouse.
FAU - Peters, G
AU  - Peters G
FAU - Brookes, S
AU  - Brookes S
FAU - Smith, R
AU  - Smith R
FAU - Dickson, C
AU  - Dickson C
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Animals
MH  - Chromosomes/*analysis
MH  - Cloning, Molecular
MH  - DNA, Viral/*analysis
MH  - Mammary Neoplasms, Experimental/*genetics
MH  - Mammary Tumor Virus, Mouse/*genetics
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Molecular Weight
EDAT- 1983/06/01 00:00
MHDA- 1983/06/01 00:01
CRDT- 1983/06/01 00:00
PHST- 1983/06/01 00:00 [pubmed]
PHST- 1983/06/01 00:01 [medline]
PHST- 1983/06/01 00:00 [entrez]
AID - 0092-8674(83)90418-X [pii]
AID - 10.1016/0092-8674(83)90418-x [doi]
PST - ppublish
SO  - Cell. 1983 Jun;33(2):369-77. doi: 10.1016/0092-8674(83)90418-x.