PMID- 6309173
OWN - NLM
STAT- MEDLINE
DCOM- 19830909
LR  - 20190612
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 114
IP  - 1
DP  - 1983 Jul 18
TI  - Guanosine 5'-triphosphate modulation of S-adenosyl-L-methionine-mediated 
      methylation of phosphatidylethanolamine in rat liver plasma membrane.
PG  - 425-30
AB  - Effect of guanosine 5'-triphosphate(GTP) on the S-adenosyl-L-methionine-mediated 
      methylation of phosphatidylethanolamine was examined using rat liver plasma 
      membranes. Methyltransferase I, which catalyzes methylation of 
      phosphatidylethanolamine to phosphatidyl-N-mono-methylethanolamine was inhibited 
      by GTP, whereas methyltransferase II, which transfers methyl groups from 
      S-adenosyl-L-methionine to produce phosphatidyl-N,N-dimethylethanolamine or 
      phosphatidyl-choline was stimulated by GTP. d,l-isoproterenol stimulated 
      methyl-transferase II activity slightly. This stimulation was greatly augmented 
      by GTP. d,l-isoproterenol inhibited methyltransferase I and this inhibition was 
      enhanced by GTP. The results indicate that GTP has a regulatory role in the 
      methylation of phospholipids in the plasma membrane through inactivation of 
      methyltransferase I and activation of methyltransferase II by binding to these 
      enzymes.
FAU - Hashizume, K
AU  - Hashizume K
FAU - Kobayashi, M
AU  - Kobayashi M
FAU - Ichikawa, K
AU  - Ichikawa K
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Phosphatidylethanolamines)
RN  - 7LP2MPO46S (S-Adenosylmethionine)
RN  - 86-01-1 (Guanosine Triphosphate)
RN  - C137DTR5RG (Theophylline)
RN  - E0399OZS9N (Cyclic AMP)
RN  - EC 2.1.1.- (Methyltransferases)
RN  - EC 2.1.1.17 (Phosphatidylethanolamine N-Methyltransferase)
RN  - L628TT009W (Isoproterenol)
SB  - IM
MH  - Animals
MH  - Cell Membrane/metabolism
MH  - Cyclic AMP/pharmacology
MH  - Guanosine Triphosphate/*pharmacology
MH  - Isoproterenol/pharmacology
MH  - Kinetics
MH  - Liver/*metabolism
MH  - Male
MH  - Methyltransferases/*metabolism
MH  - Phosphatidylethanolamine N-Methyltransferase
MH  - Phosphatidylethanolamines/*metabolism
MH  - Rats
MH  - Rats, Inbred Strains
MH  - S-Adenosylmethionine/*metabolism
MH  - Theophylline/pharmacology
EDAT- 1983/07/18 00:00
MHDA- 1983/07/18 00:01
CRDT- 1983/07/18 00:00
PHST- 1983/07/18 00:00 [pubmed]
PHST- 1983/07/18 00:01 [medline]
PHST- 1983/07/18 00:00 [entrez]
AID - 0006-291X(83)91644-3 [pii]
AID - 10.1016/0006-291x(83)91644-3 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 1983 Jul 18;114(1):425-30. doi: 
      10.1016/0006-291x(83)91644-3.