PMID- 6313911
OWN - NLM
STAT- MEDLINE
DCOM- 19831220
LR  - 20190511
IS  - 0022-3751 (Print)
IS  - 1469-7793 (Electronic)
IS  - 0022-3751 (Linking)
VI  - 342
DP  - 1983 Sep
TI  - The synaptic current evoked in cat spinal motoneurones by impulses in single 
      group 1a axons.
PG  - 615-32
AB  - Excitatory post-synaptic potentials (e.p.s.p.s) were evoked in motoneurones of 
      anaesthetized cats by impulses in single group 1 a axons. E.p.s.p.s with a time 
      course which indicated a somatic site of origin were voltage-clamped using a 
      single micro-electrode clamp. Excitatory post-synaptic currents (e.p.s.c.s) were 
      found to peak in less than 0.2 ms, and to decay with an exponential time course. 
      The time constant of decay was usually in the range 0.3-0.4 ms (at 37 degrees C). 
      At the resting membrane potential, an e.p.s.p. with a peak of 100 microV was 
      generated by an average peak e.p.s.c. of 330 pA. This corresponded to an average 
      peak conductance increase of 5 nS. The e.p.s.c. decreased with membrane 
      depolarization, and reversed to become an outward current at a null potential of 
      +4.6 +/- 2 mV (+/- S.E. of mean; n = 7). Membrane hyperpolarization caused the 
      peak e.p.s.c. to increase and the time constant of decay of the e.p.s.c. to 
      decrease. The total charge in the synaptic current did not increase with 
      hyperpolarization. This observation can explain earlier observations which showed 
      that the peak amplitude of the e.p.s.p. did not increase with hyperpolarization. 
      The number of ion channels opened by transmitter release at a single somatic 
      bouton was estimated to be in the range 40-240.
FAU - Finkel, A S
AU  - Finkel AS
FAU - Redman, S J
AU  - Redman SJ
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Physiol
JT  - The Journal of physiology
JID - 0266262
RN  - 0 (Ion Channels)
RN  - 0 (Receptors, Neurotransmitter)
SB  - IM
MH  - Animals
MH  - Axons/*physiology
MH  - Cats
MH  - Evoked Potentials
MH  - Ion Channels/physiology
MH  - Membrane Potentials
MH  - Motor Neurons/*physiology
MH  - Receptors, Neurotransmitter/physiology
MH  - Spinal Nerve Roots/*physiology
MH  - Synapses/*physiology
MH  - Time Factors
PMC - PMC1193980
EDAT- 1983/09/01 00:00
MHDA- 1983/09/01 00:01
PMCR- 1983/09/01
CRDT- 1983/09/01 00:00
PHST- 1983/09/01 00:00 [pubmed]
PHST- 1983/09/01 00:01 [medline]
PHST- 1983/09/01 00:00 [entrez]
PHST- 1983/09/01 00:00 [pmc-release]
AID - 10.1113/jphysiol.1983.sp014872 [doi]
PST - ppublish
SO  - J Physiol. 1983 Sep;342:615-32. doi: 10.1113/jphysiol.1983.sp014872.