PMID- 6315145
OWN - NLM
STAT- MEDLINE
DCOM- 19840107
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 277
IP  - 2
DP  - 1983 Oct 31
TI  - Central effects of dibutyryl cyclic AMP and GMP on the temperature in conscious 
      rabbits.
PG  - 311-20
AB  - Intracerebroventricular (i.c.v.) administration of dibutyryl cyclic AMP 
      (Db-cAMP)- and dibutyryl cyclic GMP (Db-cGMP)-induced hyperthermia in rabbits. 
      Central administration of 4-(3-cyclopentyloxy-4-methoxyphenyl)-2-pyrrolidone (ZK 
      62711), a selective inhibitor of cAMP phosphodiesterase, only accentuated the 
      hyperthermia due to Db-cAMP whereas a selective inhibitor of cGMP 
      phosphodiesterase, 2-O-proproxyphenyl-8-azapurin-6-one (M and B 22948), only 
      potentiated the hyperthermia caused by Db-cGMP. The hyperthermia due to Db-cAMP 
      and Db-cGMP was not mediated through prostaglandins (PG). In contrast, central 
      administration of an alpha-adrenergic receptor antagonist, phenoxybenzamine, or a 
      beta-adrenergic receptor antagonist, sotalol, only attenuated the hyperthermic 
      response to Db-cAMP while a cholinergic muscarinic receptor antagonist, atropine, 
      specifically antagonized Db-cGMP-induced hyperthermia. I.c.v. administration of a 
      protein synthesis inhibitor, anisomycin, did inhibit the hyperthermia due to 
      Db-cAMP and Db-cGMP. Opiate antagonist, naloxone, did not antagonize Db-cAMP- and 
      Db-cGMP-induced hyperthermia. These results suggest that a protein mediator is 
      implicated in the induction of hyperthermia by Db-cAMP and Db-cGMP and that cAMP 
      and cGMP may be involved through alpha/beta-adrenergic and cholinergic muscarinic 
      receptors respectively in the central regulation of heat production/conservation 
      in rabbits.
FAU - Kandasamy, S B
AU  - Kandasamy SB
FAU - Williams, B A
AU  - Williams BA
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Phosphodiesterase Inhibitors)
RN  - 0 (Prostaglandins E)
RN  - 0 (Receptors, Neurotransmitter)
RN  - 0TTZ664R7Z (Phenoxybenzamine)
RN  - 32266-35-6 (Dibutyryl Cyclic GMP)
RN  - 36B82AMQ7N (Naloxone)
RN  - 63X7MBT2LQ (Bucladesine)
RN  - 6C74YM2NGI (Anisomycin)
RN  - 7C0697DR9I (Atropine)
RN  - A6D97U294I (Sotalol)
RN  - H2D2X058MU (Cyclic GMP)
RN  - K7Q1JQR04M (Dinoprostone)
RN  - W9YXS298BM (Tubocurarine)
RN  - XXE1CET956 (Indomethacin)
SB  - IM
MH  - Animals
MH  - Anisomycin/pharmacology
MH  - Atropine/pharmacology
MH  - Body Temperature Regulation/*drug effects
MH  - Brain/*drug effects
MH  - Bucladesine/*pharmacology
MH  - Cyclic GMP/*analogs & derivatives
MH  - Dibutyryl Cyclic GMP/*pharmacology
MH  - Dinoprostone
MH  - Indomethacin/pharmacology
MH  - Injections, Intraventricular
MH  - Male
MH  - Naloxone/pharmacology
MH  - Phenoxybenzamine/pharmacology
MH  - Phosphodiesterase Inhibitors/pharmacology
MH  - Prostaglandins E/pharmacology
MH  - Rabbits
MH  - Receptors, Neurotransmitter/*drug effects
MH  - Sotalol/pharmacology
MH  - Tubocurarine/pharmacology
OID - NASA: 84054387
EDAT- 1983/10/31 00:00
MHDA- 1983/10/31 00:01
CRDT- 1983/10/31 00:00
PHST- 1983/10/31 00:00 [pubmed]
PHST- 1983/10/31 00:01 [medline]
PHST- 1983/10/31 00:00 [entrez]
AID - 0006-8993(83)90939-3 [pii]
AID - 10.1016/0006-8993(83)90939-3 [doi]
PST - ppublish
SO  - Brain Res. 1983 Oct 31;277(2):311-20. doi: 10.1016/0006-8993(83)90939-3.