PMID- 6315513
OWN - NLM
STAT- MEDLINE
DCOM- 19840126
LR  - 20190515
IS  - 0012-1797 (Print)
IS  - 0012-1797 (Linking)
VI  - 32
IP  - 11
DP  - 1983 Nov
TI  - Carbohydrate oxidation and storage in obese non-insulin-dependent diabetic 
      patients. Effects of improving glycemic control.
PG  - 982-7
AB  - We have determined total body carbohydrate and lipid oxidation rates in response 
      to a standard breakfast in nine obese patients with non-insulin-dependent 
      diabetes mellitus (NIDDM) and in seven age- and weight-matched controls. The 
      patients with NIDDM were studied twice, once while in poor glycemic control 
      (fasting blood glucose concentration 267 +/- 24 mg/dl, urinary glucose excretion 
      28.9 +/- 6.3 g/24 h) and again after modest glycemic improvement following 2 mo 
      of fiber treatment (fasting blood glucose 227 +/- 19 mg/dl, urinary glucose 
      excretion 10.7 +/- 1.9 g/24 h). Basal carbohydrate (CHO) oxidation rates were 
      normal in patients with NIDDM before and after fiber treatment. However, in 
      patients before fiber treatment the rise in CHO oxidation rates, the reciprocal 
      fall in lipid oxidation rates, and the rise in serum insulin and C-peptide 
      concentrations after the breakfast were all severely blunted. In addition, 
      storage of ingested CHO was significantly reduced (from 55% to 32%, P less than 
      0.05). After fiber treatment, postbreakfast CHO oxidation rates had improved and 
      were no longer significantly lower than control values. In contrast, CHO storage 
      remained suppressed. We conclude that (1) basal CHO oxidation remained normal but 
      that postbreakfast CHO oxidation was impaired in our obese patients with NIDDM. 
      This impairment, however, appeared to be a relatively late event, occurring only 
      during severely uncontrolled NIDDM. (2) Inability to dispose of CHO by storage 
      appeared to be an earlier defect with a greater impact on glucose tolerance than 
      the impairment of CHO oxidation.
FAU - Boden, G
AU  - Boden G
FAU - Ray, T K
AU  - Ray TK
FAU - Smith, R H
AU  - Smith RH
FAU - Owen, O E
AU  - Owen OE
LA  - eng
GR  - AM 19397/AM/NIADDK NIH HHS/United States
GR  - AM 25386/AM/NIADDK NIH HHS/United States
GR  - RR 349/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Diabetes
JT  - Diabetes
JID - 0372763
RN  - 0 (Blood Glucose)
RN  - 0 (C-Peptide)
RN  - 0 (Dietary Fiber)
RN  - 0 (Fatty Acids, Nonesterified)
RN  - 0 (Insulin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Blood Glucose/*metabolism
MH  - C-Peptide/blood
MH  - Calorimetry/methods
MH  - *Carbohydrate Metabolism
MH  - Diabetes Mellitus/diet therapy/*metabolism
MH  - Diabetes Mellitus, Type 2/diet therapy/*metabolism
MH  - Dietary Fiber/administration & dosage
MH  - Eating
MH  - Fatty Acids, Nonesterified/blood
MH  - Female
MH  - Humans
MH  - Insulin/blood
MH  - Lipid Metabolism
MH  - Male
MH  - Middle Aged
MH  - *Obesity
MH  - Oxidation-Reduction
EDAT- 1983/11/01 00:00
MHDA- 1983/11/01 00:01
CRDT- 1983/11/01 00:00
PHST- 1983/11/01 00:00 [pubmed]
PHST- 1983/11/01 00:01 [medline]
PHST- 1983/11/01 00:00 [entrez]
AID - 10.2337/diab.32.11.982 [doi]
PST - ppublish
SO  - Diabetes. 1983 Nov;32(11):982-7. doi: 10.2337/diab.32.11.982.