PMID- 6318909
OWN - NLM
STAT- MEDLINE
DCOM- 19840319
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 290
IP  - 1
DP  - 1984 Jan 2
TI  - Beneficial effect of i.c.v. naloxone in anaphylactic shock is mediated through 
      peripheral beta-adrenoceptive mechanisms.
PG  - 191-4
AB  - Intracerebroventricular (i.c.v.) administration of 10 micrograms naloxone 
      significantly improved survival following experimental anaphylaxis in mice. The 
      protective effect of i.c.v. naloxone was reversed by treatments which disrupted 
      sympathetic outflow to the adrenal medulla, i.e. ganglionic blockade by 
      chorisondamine chloride or denervation of the adrenal glands or by inhibition of 
      beta-adrenoceptive sites by propranolol. These results indicate that naloxone's 
      beneficial effect in anaphylactic shock involves central actions which are 
      peripherally mediated through activation of beta-adrenoceptive mechanisms.
FAU - Amir, S
AU  - Amir S
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Receptors, Adrenergic, alpha)
RN  - 0 (Receptors, Adrenergic, beta)
RN  - 36B82AMQ7N (Naloxone)
RN  - JD3M24F66I (Chlorisondamine)
SB  - IM
MH  - Adrenal Medulla/*physiopathology
MH  - Anaphylaxis/*drug therapy
MH  - Animals
MH  - Chlorisondamine/administration & dosage
MH  - Denervation
MH  - Injections, Intraventricular
MH  - Male
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Naloxone/*therapeutic use
MH  - Receptors, Adrenergic, alpha/physiology
MH  - Receptors, Adrenergic, beta/*physiology
MH  - Sympathetic Nervous System/*physiopathology
EDAT- 1984/01/02 00:00
MHDA- 1984/01/02 00:01
CRDT- 1984/01/02 00:00
PHST- 1984/01/02 00:00 [pubmed]
PHST- 1984/01/02 00:01 [medline]
PHST- 1984/01/02 00:00 [entrez]
AID - 0006-8993(84)90754-6 [pii]
AID - 10.1016/0006-8993(84)90754-6 [doi]
PST - ppublish
SO  - Brain Res. 1984 Jan 2;290(1):191-4. doi: 10.1016/0006-8993(84)90754-6.